Domperidone in Treating Patients With Gastrointestinal Disorders

  • STATUS
    Recruiting
  • participants needed
    200
  • sponsor
    M.D. Anderson Cancer Center
Updated on 30 November 2021
nausea and vomiting
nausea
bloating
gastrointestinal disorder
dyspepsia
heartburn
gastroesophageal reflux
reflux
domperidone
potassium
urea
respiratory symptoms
vomiting
gastroesophageal reflux disease
asat
blood urea nitrogen
esophagitis
gastrointestinal disorders
acidity
gastrointestinal disease
gastric disorder
gastroparesis
magnesium level

Summary

This phase III trial studies how well domperidone works in treating patients with gastrointestinal disorders. Domperidone may help control chronic gastrointestinal disorders and their symptoms, such as pain, bloating, and nausea and vomiting, by stimulating contraction of the stomach to increase its ability to empty itself of food.

Description

PRIMARY OBJECTIVES:

I. To provide treatment with domperidone to patients >= 16 years of age where, according to the investigators' judgment, a prokinetic effect is needed for the relief of gastrointestinal (GI) motility disorders.

OUTLINE

Patients receive domperidone orally (PO) thrice daily (TID) or four times daily (QID). Treatment continues in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up for at least 30 days.

Details
Condition Gastroenteritis, Gastroparesis, Gastroesophageal Reflux, GASTROINTESTINAL DISORDER, Dyspepsia, Digestive System Disease, Heartburn, Gastropathy, Esophagitis, Stomach Discomfort, Gastroesophageal Reflux Disease (GERD), Gastrointestinal Diseases and Disorders, Diabetic Gastroparesis, Nausea and Vomiting, Heartburn (Pediatric), Non-Ulcer Dyspepsia (NUD), gastroesophageal reflux disease, esophageal reflux, gerd, gastric reflux, gastro-oesophageal reflux, delayed gastric emptying, gastric atony, acidity, nausea/vomiting, gastrointestinal diseases, gastrointestinal disorders, gastrointestinal disease, digestive disorders, digestive diseases, digestive disorder, digestive disease
Treatment questionnaire administration, Questionnaires, Domperidone, Phone Calls
Clinical Study IdentifierNCT01696734
SponsorM.D. Anderson Cancer Center
Last Modified on30 November 2021

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