Last updated on February 2018

Osteonecroses in Pediatric Patients With ALL

Brief description of study

Nowadays approximately 80% of children and adolescents with acute lymphoblastic leukaemia (ALL) or lymphoblastic lymphoma (LBL) can be cured and become long-term survivors. Avascular osteonecroses (ON) appear as serious side-effect of antileukaemic treatment. Frequently ON are first diagnosed at higher and than irreversible stages (ARCO III, IV). At these advanced stages curative treatment options are not available. Hence ON are associated with considerable morbidity concerning pain and immobility and go along with long-term impairment of quality of life. Therefore early diagnosis of ON in the follow-up of children and young adults with ALL or LBL is a pressing object.

Within the prospective multicentric observational OPAL-trial patients at risk (aged 10 years or older) treated according to the clinical trials ALL-BFM(Berlin-Frankfurt-Muenster Study Group), COALL or NHL (Non Hodgkin Lymphoma)-BFM in Germany should be examined with regard to the development of ON. By using a treatment associated, risk orientated assessment and examination incidence, symptoms and the clinical course of ON are investigated. The validity of MRI screening in the early diagnosis of ON in children and young adults is analysed.

Systematical investigation of patients under antileukaemic treatment is intended to contribute to risk adapted diagnostic strategies and to serve as data base for the subsequent evaluation of preventive and interventional approaches for the treatment of ON. Long-term objective is the reduction of ON-associated morbidity.

Clinical Study Identifier: NCT01619124

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Rolf Mertens, Prof. Dr.

Department of Paediatric and Adolescend Medicine, University Aachen
Aachen, Germany
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Carola Weber, Dr. med.

Department of Pediatrics, Haematology and Oncology, University Bonn
Bonn, Germany
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André Hofmann, Dr. med.

Department for Children and Adolescent Helth Chemnitz gGmbH
Chemnitz, Germany
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Thomas Wiesel, Dr.

Clinic of Pediatric and Adolescent Medicine, Vestische Caritas Clinic Datteln
Datteln, Germany
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Meinolf Suttorp, Prof. Dr.

Division of Pediatric Hematology and Oncology, University Children s Hospital
Dresden, Germany
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Michaela Kuhlen, Dr. med.

Clinic of Pediatric Oncology, Hematology and Clinical Immunology, Center for Child and Adolescent Health, Heinrich Heine University
Duesseldorf, Germany
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M. Metzler, Dr.

Clinic of Pediatrics and Adolescent , Pediatric Hematology and Oncology
Erlangen, Germany
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M. Schündeln, Dr.

Department of Pediatric-Oncology/-Hematology and clin. Immunology, University Medicine Essen
Essen, Germany
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Thomas Klingebiel, Prof. Dr.

Department of Pediatric Hematology, Oncology and Hemostaseology, Goethe-University, University Children's Hospital
Frankfurt/Main, Germany
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Hagen Graf Einsiedel, Dr.

Pediatric Hematology and Oncology, University Medicine Greifswald
Greifswald, Germany
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Gabriele Escherich, Dr.

Clinic of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf
Hamburg, Germany
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Wolfgang Behnisch, Dr.

Department of Pediatric and Adolescent Helth, University Medical Center Heidelberg
Heidelberg, Germany
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Alfred Längler, Dr. med.

Clinic and Polyclinic of Oncology and Haematology, Herdecke
Herdecke, Germany
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Norbert Graf, Prof. Dr.

Children's Hospital Medical Center, Pediatric Haematology and Oncology
Homburg, Germany
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Michaela Nathrath, Prof.

Clinic of Pediatric Hematology and Oncology, Kassel
Kassel, Germany
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Gunnar Cario, Dr.

Department of Pediatrics, University Medicine of Schleswig-Holstein, Campus Kiel
Kiel, Germany
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Rudolf Ferrari, Dr.

Clinic of Pediatric and Adolescent Helth, Koblenz-Mayen
Koblenz, Germany
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Thomas Imschweiler, Dr.

Helios Klinikum Krefeld Department of Paediatric and Adolescent Medicine
Krefeld, Germany
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Bernhard Erdlenbruch, Prof. Dr.

Clinic of Oncology and Hematology, Johannes Wesling Klinikum
Minden, Germany
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Wolfram Scheurlen, Prof.Dr.

Department of Paediatric Oncology and Hematology, Cnopf`sche Kinderklinik
Neuendettelsau, Germany
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H. Müller, Prof. Dr.

Department of General Pediatrics, Hematology and Oncology Oldenburg gGmbH
Oldenburg, Germany
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Carl-Friedrich Classen, Dr.

Clinic of Paediatric and Adolescend, University Rostock
Rostock, Germany
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Christian Güttel, Dr.

Clinic of Paediatric Oncology and Hematology, Helios Klinikum Schwerin
Schwerin, Germany
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Stefan Weis, Dr.

Clinic Trier, Klinikum Mutterhaus der Brom erinnen
Trier, Germany
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Daniel Steinbach, Prof. Dr.

Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm
Ulm, Germany
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Recruitment Status: Open

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