Last updated on February 2018

Osteonecroses in Pediatric Patients With ALL


Brief description of study

Nowadays approximately 80% of children and adolescents with acute lymphoblastic leukaemia (ALL) or lymphoblastic lymphoma (LBL) can be cured and become long-term survivors. Avascular osteonecroses (ON) appear as serious side-effect of antileukaemic treatment. Frequently ON are first diagnosed at higher and than irreversible stages (ARCO III, IV). At these advanced stages curative treatment options are not available. Hence ON are associated with considerable morbidity concerning pain and immobility and go along with long-term impairment of quality of life. Therefore early diagnosis of ON in the follow-up of children and young adults with ALL or LBL is a pressing object.

Within the prospective multicentric observational OPAL-trial patients at risk (aged 10 years or older) treated according to the clinical trials ALL-BFM(Berlin-Frankfurt-Muenster Study Group), COALL or NHL (Non Hodgkin Lymphoma)-BFM in Germany should be examined with regard to the development of ON. By using a treatment associated, risk orientated assessment and examination incidence, symptoms and the clinical course of ON are investigated. The validity of MRI screening in the early diagnosis of ON in children and young adults is analysed.

Systematical investigation of patients under antileukaemic treatment is intended to contribute to risk adapted diagnostic strategies and to serve as data base for the subsequent evaluation of preventive and interventional approaches for the treatment of ON. Long-term objective is the reduction of ON-associated morbidity.

Clinical Study Identifier: NCT01619124

Contact Investigators or Research Sites near you

Start Over

Rolf Mertens, Prof. Dr.

Department of Paediatric and Adolescend Medicine, University Aachen
Aachen, Germany
  Connect »

Carola Weber, Dr. med.

Department of Pediatrics, Haematology and Oncology, University Bonn
Bonn, Germany
  Connect »

André Hofmann, Dr. med.

Department for Children and Adolescent Helth Chemnitz gGmbH
Chemnitz, Germany
  Connect »

Thomas Wiesel, Dr.

Clinic of Pediatric and Adolescent Medicine, Vestische Caritas Clinic Datteln
Datteln, Germany
  Connect »

Meinolf Suttorp, Prof. Dr.

Division of Pediatric Hematology and Oncology, University Children s Hospital
Dresden, Germany
  Connect »

Michaela Kuhlen, Dr. med.

Clinic of Pediatric Oncology, Hematology and Clinical Immunology, Center for Child and Adolescent Health, Heinrich Heine University
Duesseldorf, Germany
  Connect »

M. Metzler, Dr.

Clinic of Pediatrics and Adolescent , Pediatric Hematology and Oncology
Erlangen, Germany
  Connect »

M. Schündeln, Dr.

Department of Pediatric-Oncology/-Hematology and clin. Immunology, University Medicine Essen
Essen, Germany
  Connect »

Thomas Klingebiel, Prof. Dr.

Department of Pediatric Hematology, Oncology and Hemostaseology, Goethe-University, University Children's Hospital
Frankfurt/Main, Germany
  Connect »

Hagen Graf Einsiedel, Dr.

Pediatric Hematology and Oncology, University Medicine Greifswald
Greifswald, Germany
  Connect »

Gabriele Escherich, Dr.

Clinic of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf
Hamburg, Germany
  Connect »

Wolfgang Behnisch, Dr.

Department of Pediatric and Adolescent Helth, University Medical Center Heidelberg
Heidelberg, Germany
  Connect »

Alfred Längler, Dr. med.

Clinic and Polyclinic of Oncology and Haematology, Herdecke
Herdecke, Germany
  Connect »

Norbert Graf, Prof. Dr.

Children's Hospital Medical Center, Pediatric Haematology and Oncology
Homburg, Germany
  Connect »

Michaela Nathrath, Prof.

Clinic of Pediatric Hematology and Oncology, Kassel
Kassel, Germany
  Connect »

Gunnar Cario, Dr.

Department of Pediatrics, University Medicine of Schleswig-Holstein, Campus Kiel
Kiel, Germany
  Connect »

Rudolf Ferrari, Dr.

Clinic of Pediatric and Adolescent Helth, Koblenz-Mayen
Koblenz, Germany
  Connect »

Thomas Imschweiler, Dr.

Helios Klinikum Krefeld Department of Paediatric and Adolescent Medicine
Krefeld, Germany
  Connect »

Bernhard Erdlenbruch, Prof. Dr.

Clinic of Oncology and Hematology, Johannes Wesling Klinikum
Minden, Germany
  Connect »

Wolfram Scheurlen, Prof.Dr.

Department of Paediatric Oncology and Hematology, Cnopf`sche Kinderklinik
Neuendettelsau, Germany
  Connect »

H. Müller, Prof. Dr.

Department of General Pediatrics, Hematology and Oncology Oldenburg gGmbH
Oldenburg, Germany
  Connect »

Carl-Friedrich Classen, Dr.

Clinic of Paediatric and Adolescend, University Rostock
Rostock, Germany
  Connect »

Christian Güttel, Dr.

Clinic of Paediatric Oncology and Hematology, Helios Klinikum Schwerin
Schwerin, Germany
  Connect »

Stefan Weis, Dr.

Clinic Trier, Klinikum Mutterhaus der Brom erinnen
Trier, Germany
  Connect »

Daniel Steinbach, Prof. Dr.

Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm
Ulm, Germany
  Connect »

Recruitment Status: Open


Brief Description Eligibility Contact Research Team


Receive Emails About New Clinical Trials!

Sign up for our FREE service to receive email notifications when clinical trials are posted in the medical category of interest to you.