Last updated on August 2018

Doxycycline Treatment to Prevent Progressive Coronary Artery Dilation in Children With Kawasaki Disease


Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Kawasaki Disease | Coronary artery aneurysm
  • Age: Between 1 - 18 Years
  • Gender: Male or Female

Inclusion Criteria:

Treatment arm: Patients aged 1 month to 18 years with confirmed KD will be included in the study if they meet the following criteria:

  1. Patients with dilation of the right or left anterior descending coronary artery beyond a z-score of +3 during the acute febrile phase of KD.
  2. Patients with aneurysms of the right or left main coronary arteries during the acute febrile phase of KD.
  3. Patients with refractory KD after initial treatment with IVIG and dilated coronary arteries on an echocardiogram during the first month of KD.

Comparison arm: Patients aged 1 month to 18 years with confirmed KD, who do not meet inclusion criteria to be included in the treatment group.

1.Patients with right or left anterior descending coronary artery measurements below a z-score of +3 during the acute febrile phase of KD.

Exclusion Criteria:

The following patients will be excluded from this study:

  1. Patients with clinically incomplete KD.
  2. Patients whose parents refuse to administer doxycycline.
  3. Patients with acute renal failure.
  4. Patients with chronic liver and kidney disease.

Recruitment Status: Open


Brief Description Eligibility Contact Research Team


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