Last updated on February 2019

Prospective Study of Clinically Nonfunctioning Pituitary Adenomas


Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Pituitary Adenoma
  • Age: Between 18 - 100 Years
  • Gender: Male or Female

GROUP I

Inclusion Criteria:

  • adult patients with pituitary lesions that do not require surgical intervention.
  • pituitary lesion that has been demonstrated on a magnetic resonance imaging (MRI) to be consistent with an adenoma (not a cystic lesion such as a Rathke's cleft cyst).
  • patients with macroadenomas (> 1 cm) or large microadenomas 6-9 mm.
  • a prolactin level < 40 ng/ml.

Exclusion Criteria:

  • presence of visual or neurological deficits due to the tumor, tumor impingement on the optic chiasm and physical or laboratory abnormalities consistent with a biologically active hormone secreting tumor.

GROUP II

Inclusion Criteria:

  • adult patients with pituitary lesions that require surgical intervention and are planning on surgery or who had surgery in the past and are now undergoing pituitary radiotherapy.
  • pre-surgery patients will have a pituitary lesion that has been demonstrated on a MRI to be consistent with an adenoma (not a cystic lesion such as a Rathke's cleft cyst) and that is a macroadenoma (> 1 cm).
  • presence of visual or neurological deficits due to the tumor or impingement of the tumor on the optic chiasm is permitted.
  • a prolactin level < 100 ng/ml if lesion is > or = 10 mm in size or a prolactin level < 40 ng/ml if lesion is < 10 mm in size.
  • patients with mild/moderate hyperprolactinemia and recommended for dopamine agonist therapy (on the chance that the lesion is truly a prolactinoma) may re-enter the study should they be a dopamine agonist failure and require surgery.
  • patients with hypopituitarism and no other surgical indication that choose to undergo surgery is permitted.

Recruitment Status: Open


Brief Description Eligibility Contact Research Team


Volunteer Sign-up

Sign up for our FREE service to receive email notifications when clinical trials are posted in the medical category of interest to you.