Elucidating Kisspeptin Physiology by Blocking Kisspeptin Signaling

  • STATUS
    Not Recruiting
  • End date
    Sep 8, 2023
  • participants needed
    411
  • sponsor
    Massachusetts General Hospital
Updated on 20 July 2022
estradiol
reproductive hormones
testicular
klinefelter syndrome
secondary hypogonadism
kisspeptin
screening procedure

Summary

The investigators are looking for subjects to complete a study on the role of kisspeptin in the reproductive system. Kisspeptin is a naturally occurring hormone in humans that tells the body to produce other reproductive hormones. However, giving someone a continued amount of kisspeptin over a period of time can have the opposite effect and tell the body to, for a short time, stop making hormones needed for reproduction. By giving 24-hour infusions of kisspeptin, the investigators hope to learn more about the role kisspeptin has in the way bodies function normally and the role it has in conditions that affect the reproductive system.

Description

Please contact study staff for a detailed description.

Details
Condition hypogonadotropic hypogonadism, Klinefelter's Syndrome, Agonadism, secondary hypogonadism, Primary Gonadal Insufficiency in Men, Healthy Postmenopausal Women, Hypogonadism, Hypergonadotropic Hypogonadism in Men, klinefelter syndrome
Treatment kisspeptin 112-121, GnRH
Clinical Study IdentifierNCT01438073
SponsorMassachusetts General Hospital
Last Modified on20 July 2022

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