Elucidating Kisspeptin Physiology by Blocking Kisspeptin Signaling

  • STATUS
    Recruiting
  • End date
    Sep 28, 2023
  • participants needed
    411
  • sponsor
    Massachusetts General Hospital
Updated on 28 January 2021
estradiol
reproductive hormones
testicular
klinefelter syndrome
secondary hypogonadism
kisspeptin
screening procedure

Summary

The investigators are looking for subjects to complete a study on the role of kisspeptin in the reproductive system. Kisspeptin is a naturally occurring hormone in humans that tells the body to produce other reproductive hormones. However, giving someone a continued amount of kisspeptin over a period of time can have the opposite effect and tell the body to, for a short time, stop making hormones needed for reproduction. By giving 24-hour infusions of kisspeptin, the investigators hope to learn more about the role kisspeptin has in the way bodies function normally and the role it has in conditions that affect the reproductive system.

Description

Please contact study staff for a detailed description.

Details
Condition Hypogonadism, Klinefelter's Syndrome, Healthy Postmenopausal Women, Primary Gonadal Insufficiency in Men, Hypergonadotropic Hypogonadism in Men, Agonadism, hypogonadotropic hypogonadism, klinefelter syndrome, secondary hypogonadism
Treatment kisspeptin 112-121, GnRH
Clinical Study IdentifierNCT01438073
SponsorMassachusetts General Hospital
Last Modified on28 January 2021

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