Studies of States With Resistance to Vitamin D and Parathyroid Hormone

  • STATUS
    Recruiting
  • participants needed
    3000
  • sponsor
    National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Updated on 16 October 2022
calcium
vitamin d
vitamin
parathyroid hormone

Summary

Patients with confirmed or suspected states with resistance to vitamin D or parathyroid hormone (PTH) will be admitted for diagnosis, treatment review with suggestions for modifications to the current or new treatment and for inclusion in other protocols. These states include hypocalcemia, rickets, osteomalacia, pseudohypoparathyroidism. Resistance to a factor is manifested by deficient bioeffect despite high levels of the factor in blood. Patients will be tested with multiple indices of mineral metabolism to establish the diagnosis and examine the spectrum of the underlying disorder. The principal therapies will be combinations of calcium, phosphate, and a vitamin D analog. Selected patients will have localization and surgery to remove a tumor that causes renal wasting of phosphate. Patients will also be considered for entry into other research protocols.

Description

Patients with confirmed or suspected states with resistance to vitamin D or parathyroid hormone (PTH) will be admitted for diagnosis, treatment review with suggestions for modifications to the current or new treatment and for inclusion in other protocols. These states include hypocalcemia, rickets, osteomalacia, pseudohypoparathyroidism. Resistance to a factor is manifested by deficient bioeffect despite high levels of the factor in blood. Patients will be tested with multiple indices of mineral metabolism to establish the diagnosis and examine the spectrum of the underlying disorder. The principal therapies will be combinations of calcium, phosphate, and a vitamin D analog. Selected patients will have localization and surgery to remove a tumor that causes renal wasting of phosphate. Patients will also be considered for entry into other research protocols.

Details
Condition Hypocalcemia, Pseudohypoparathyroidism, Osteomalacia, Rickets, Pseudopseudohpoparathyroidism
Clinical Study IdentifierNCT00001242
SponsorNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Last Modified on16 October 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Patients, from 2 months to 100 years of age, of either sex M or F, with vitamin D
resistance, rickets, osteomalacia, pseudohypoparathyroidism
pseudo-pseudohypoparathyroidism, or suspicion of these or related disorders based upon the
appropriateness of their problem to ongoing investigations
Current investigations are focused principally upon the inclusion of subjects with, or
suspected of having, hypocalcemia likely due to a resistance to parathyroid hormone
including subjects who have a diagnosis, or likely diagnosis, of pseudohypoparathyroidism
or pseudopseudohypoparathyroidism
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