Evaluation of the Genetics of Bipolar Disorder

  • participants needed
  • sponsor
    National Institute of Mental Health (NIMH)
Updated on 30 April 2021
drugs of abuse
drug abuse
bipolar disorder
depressed mood
panic disorder
neurological disorder


This study looks to identify genes that may affect a person's chances of developing bipolar disorder (BP) and related conditions.


Bipolar affective disorder is a severe, heritable condition affecting about one percent of

the population. The mode of inheritance is poorly understood and probably involves multiple loci of small to moderate effect. In this project, we use genetic mapping and sequencing methods to identify genetic markers and variations that contribute to the risk of bipolar disorder. Individuals diagnosed with bipolar disorder are studied, along with their relatives. Phenotypic information obtained from clinical interviews and family history is correlated with genotypic information obtained from genetic marker and sequencing methods. The goal is to identify genes involved in bipolar disorder and related conditions so that better methods of diagnosis, treatment, and prevention can be developed.

Condition mood disorder, Endogenous depression, Depression, Bipolar Disorder, Depression (Major/Severe), Depression (Adolescent), Depression (Pediatric), Depression (Adult and Geriatric), Depression (Treatment-Resistant), Schizoaffective, Bipolar Disorders (Pediatric), Mood Disorders (Pediatric), Affective Disorders, Manic Disorders, Mood Disorders
Clinical Study IdentifierNCT00001174
SponsorNational Institute of Mental Health (NIMH)
Last Modified on30 April 2021


Yes No Not Sure

Inclusion Criteria

Age > 18 yr
Able to provide informed consent
Bipolar disorder or related conditions not attributable to substance abuse
neurological disease; or a 1st or 2nd degree relative of an enrolled
participant. Related conditions are defined as those found more often among
relatives of people with bipolar disorder or which have been shown to be
genetically correlated with bipolar disorder through molecular genetic
studies. These include major depression, schizophrenia, panic disorder, and
attention deficit hyperactivity disorder
Able to safely provide a blood or saliva sample

Exclusion Criteria

Active alcohol or substance abuse
NIMH employees/staff and their immediate family members will be excluded from
the study per NIMH policy
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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