Evaluation of the Genetics of Bipolar Disorder

  • STATUS
    Recruiting
  • participants needed
    4000
  • sponsor
    National Institute of Mental Health (NIMH)
Updated on 30 April 2021
depression
drugs of abuse
drug abuse
bipolar disorder
depressed mood
schizophrenia
panic disorder
neurological disorder

Summary

This study looks to identify genes that may affect a person's chances of developing bipolar disorder (BP) and related conditions.

Description

Bipolar affective disorder is a severe, heritable condition affecting about one percent of

the population. The mode of inheritance is poorly understood and probably involves multiple loci of small to moderate effect. In this project, we use genetic mapping and sequencing methods to identify genetic markers and variations that contribute to the risk of bipolar disorder. Individuals diagnosed with bipolar disorder are studied, along with their relatives. Phenotypic information obtained from clinical interviews and family history is correlated with genotypic information obtained from genetic marker and sequencing methods. The goal is to identify genes involved in bipolar disorder and related conditions so that better methods of diagnosis, treatment, and prevention can be developed.

Details
Condition mood disorder, Endogenous depression, Depression, Bipolar Disorder, Depression (Major/Severe), Depression (Adolescent), Depression (Pediatric), Depression (Adult and Geriatric), Depression (Treatment-Resistant), Schizoaffective, Bipolar Disorders (Pediatric), Mood Disorders (Pediatric), Affective Disorders, Manic Disorders, Mood Disorders
Clinical Study IdentifierNCT00001174
SponsorNational Institute of Mental Health (NIMH)
Last Modified on30 April 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Age > 18 yr
Able to provide informed consent
Bipolar disorder or related conditions not attributable to substance abuse
neurological disease; or a 1st or 2nd degree relative of an enrolled
participant. Related conditions are defined as those found more often among
relatives of people with bipolar disorder or which have been shown to be
genetically correlated with bipolar disorder through molecular genetic
studies. These include major depression, schizophrenia, panic disorder, and
attention deficit hyperactivity disorder
Able to safely provide a blood or saliva sample

Exclusion Criteria

Active alcohol or substance abuse
NIMH employees/staff and their immediate family members will be excluded from
the study per NIMH policy
Clear my responses

How to participate?

Step 1 Connect with a site
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar
Name

Primary Contact

site
Name

Phone Email

0/250
Preferred Language
Other Language
Please verify that you are not a bot.

Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider

Loading...

Browse trials for

Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 

 • 

Private

Reply by • Private
Loading...

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.
Loading...

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note