Development of Ovarian Tissue Autograft in Order to Restore Ovarian Function

  • End date
    Oct 4, 2022
  • participants needed
  • sponsor
    Centre Hospitalier Universitaire de Besancon
Updated on 4 February 2021


Ovarian cryopreservation is one of the available option for preserving fertility prior to potentially sterilizing treatments. In the absence of other techniques such as in vitro folliculogenesis or injection of isolated ovarian follicles, this tissue can only be re-used by autograft. In France, the first live birth after orthotopic ovarian transplantation, was obtained by Roux et al. in 2009. This clinical trial aims to collect data on the efficiency of the graft in terms of restoration of ovarian function and live births. It will also allow us to carry out the patient follow-up after ovarian tissue cryopreservation and after autograft when achieved. In cases of neoplastic malignancies, minimal residual disease detection will be performed on ovarian tissue, to avoid any risk of cancer re-seeding.

Condition Ovarian Function Insufficiency
Treatment Autograft of cryopreserved ovarian tissue
Clinical Study IdentifierNCT02846064
SponsorCentre Hospitalier Universitaire de Besancon
Last Modified on4 February 2021


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Inclusion Criteria

Patients who underwent Ovarian tissue cryopreservation
Premature ovarian failure
Patients cured of their primary disease
Women between 18 and 43 years of age
Patients who have already benefited from ovarian tissue autograft

Exclusion Criteria

Patients under trusteeship
Patients placed in receivers
Patients under the protection of a conservator
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