Last updated on February 2019

Combination Chemotherapy With or Without Blinatumomab in Treating Patients With Newly Diagnosed BCR-ABL-Negative B Lineage Acute Lymphoblastic Leukemia


Brief description of study

This randomized phase III trial studies combination chemotherapy with blinatumomab to see how well it works compared to induction chemotherapy alone in treating patients with newly diagnosed breakpoint cluster region (BCR)-c-abl oncogene 1, non-receptor tyrosine kinase (ABL)-negative B lineage acute lymphoblastic leukemia. Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Monoclonal antibodies, such as blinatumomab, may block cancer growth in different ways by targeting certain cells. It is not yet known whether combination chemotherapy is more effective with or without blinatumomab in treating newly diagnosed acute lymphoblastic leukemia.

Detailed Study Description

PRIMARY OBJECTIVES:

I. To compare the overall survival (OS) of blinatumomab in conjunction with chemotherapy to chemotherapy alone in patients with BCR-ABL-negative B cell precursor acute lymphoblastic leukemia (ALL) who are minimal residual disease (MRD) positive after induction and intensification chemotherapy, based on multiparameter flow cytometric (MFC) assessment of residual blasts.

II. If superiority of blinatumomab in the MRD positive group is shown, to compare the OS of blinatumomab in conjunction with chemotherapy to chemotherapy alone in patients with BCR-ABL-negative B cell precursor ALL who are MRD negative after induction and intensification chemotherapy, based on MFC assessment of residual blasts.

III. If superiority of blinatumomab in the MRD positive group is not shown, to compare the OS of blinatumomab in conjunction with chemotherapy to chemotherapy alone in the overall population of patients with BCR-ABL-negative B cell precursor ALL.

SECONDARY OBJECTIVES:

I. To compare the relapse-free survival (RFS) of blinatumomab in conjunction with chemotherapy to chemotherapy alone in MRD positive patients, MRD negative patients and overall population after induction and intensification chemotherapy.

II. To determine if blinatumomab can convert patients who are MRD positive by MFC assessment of residual blasts after induction and intensification chemotherapy to MRD negativity.

III. To assess the toxicities of blinatumomab in this patient population. IV. To assess the toxicities of the modified E2993 chemotherapy regimen in this patient population.

V. To describe the outcome of patients who proceed to allogeneic blood or marrow transplant after treatment with or without blinatumomab.

TERTIARY OBJECTIVES:

I. To determine differences in MRD kinetics among patients with the BCR/ABL1-like B-lineage ALL, and assess the efficacy of blinatumomab in each molecular subgroup.

II. To evaluate the incidence of anti-blinatumomab antibody formation.

OUTLINE

INDUCTION CHEMOTHERAPY: Patients receive cytarabine intrathecally (IT) on day 1; daunorubicin hydrochloride intravenously (IV) over 10-15 minutes on days 1, 8, 15, and 22; vincristine sulfate IV on days 1, 8, 15, and 22; dexamethasone orally (PO) daily on days 1-7 (and 15-21 for patients age < 55 years only); methotrexate IT on day 14; pegaspargase intramuscularly (IM) or IV on day 18 (patients age =< 55 years); and CD20 positive patients may optionally receive rituximab IV on day 8 and 15. Beginning on day 29, patients with absolute neutrophil count (ANC) >= 0.75 x 10^9/L and platelets > 75 x 10^9/L (patients with delayed hematologic recovery) (patients with residual disease that is delaying count begin treatment immediately) receive cyclophosphamide IV over 30 minutes on days 1 and 29, cytarabine IV over 30 minutes or subcutaneously (SC) on days 1-4, 8-11, 29-32, and 36-39, mercaptopurine PO on days 1-14, 29-42, pegaspargase IM or IV on day 15 (patients age < 55 years), patients receiving treatment for central nervous system (CNS) 2 or 3 leukemia in course 1 receive methotrexate IT on days 1, 8, 15, and 22, and CD20 positive patients may optionally receive rituximab IV on days 8 and 15.

INTENSIFICATION THERAPY: Beginning 4 weeks after the completion of course 2 of induction therapy, patients receive intensification therapy comprising high-dose methotrexate IV over 2 hours on days 1 and 8, and pegaspargase IM or IV on day 9.

Patients are then randomized to 1 of 2 treatment arms.

Patients randomized to the blinatumomab group receive blinatumomab IV continuously on days 1-28. Treatment repeats every 6 weeks for 2 courses in the absence of disease progression or unacceptable toxicity. Patients may then undergo allogeneic stem cell transplant (SCT) or proceed to consolidation therapy per investigator discretion.

CONSOLIDATION THERAPY: Beginning after the second course of blinatumomab (patients randomized to the blinatumomab group) or after intensification therapy (patients not randomized to blinatumomab), patients receive cytarabine IV over 30 minutes or SC on days 1-5, etoposide IV over 1 hour on days 1-5, methotrexate IT on day 1, and pegaspargase IM or IV on day 5, and CD20 positive patients may optionally receive rituximab IV on day 5. Beginning 4 weeks from day 1 of course 1, patients receive cytarabine, etoposide, methotrexate, and CD20 positive patients may receive rituximab as in course 1. Beginning 4 weeks from day 1 of course 2, patients receive daunorubicin hydrochloride IV over 10-15 minutes on day 1, 8, 15, and 22; vincristine sulfate IV on days 1, 8, 15, and 22; dexamethasone PO daily on days 1-7 (and 15-21 for patients age < 55 years); methotrexate IT on day 2; cyclophosphamide PO or IV over 30 minutes on day 29; cytarabine IV over 30 minutes or SC on days 30-33 and 37-40; mercaptopurine PO on days 29-42 and CD20 positive patients may receive rituximab on day 8. Beginning 8 weeks from day 1 of course 3, patients receive cytarabine, etoposide, methotrexate, and CD20 positive patients may optionally receive rituximab as in course 1. Patients randomized to blinatumomab repeat course 4 and then receive blinatumomab IV continuously on days 1-28.

MAINTENANCE THERAPY: Within 12 weeks after beginning last course of consolidation therapy, patients receive mercaptopurine PO daily, methotrexate PO or IV over 6 hours once weekly for 2.5 years, vincristine sulfate IV on day 1 every 3 months, prednisone PO on days 1-5 every 3 months, and methotrexate IT on day 1 every 3 months. Treatment continues for up to 2.5 years in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up every 3 months for 2 years, every 6 months for 3 years, and then every 12 months for 5 years.

Clinical Study Identifier: NCT02003222

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Nikolaos Papadantonakis

University of Alabama at Birmingham Cancer Center
Birmingham, AL United States
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Alison K. Conlin

Anchorage Associates in Radiation Medicine
Anchorage, AK United States
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Alison K. Conlin

Anchorage Radiation Therapy Center
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Alison K. Conlin

Alaska Oncology and Hematology LLC
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Katmai Oncology Group
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Alison K. Conlin

Providence Alaska Medical Center
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Ravitharan Krishnadasan

University of Arizona Cancer Center-North Campus
Tucson, AZ United States
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Ravitharan Krishnadasan

The University of Arizona Medical Center-University Campus
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Muthu Veeraputhiran

University of Arkansas for Medical Sciences
Little Rock, AR United States
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John A. Ellerton

PCR Oncology
Arroyo Grande, CA United States
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Alison K. Conlin

Providence Saint Joseph Medical Center/Disney Family Cancer Center
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Matthew J. Wieduwilt

UC San Diego Moores Cancer Center
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Deepa Jeyakumar

UC Irvine Health/Chao Family Comprehensive Cancer Center
Orange, CA United States
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Michaela Liedtke

Stanford Cancer Institute Palo Alto
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Steven D. Gore

Smilow Cancer Hospital Care Center at Saint Francis
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Steven D. Gore

Yale University
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Sibley Memorial Hospital
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Emory University Hospital/Winship Cancer Institute
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Northside Hospital
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Saint Luke's Mountain States Tumor Institute
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Kootenai Medical Center
Coeur d'Alene, ID United States
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Saint Luke's Mountain States Tumor Institute - Fruitland
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Saint Luke's Mountain States Tumor Institute - Meridian
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Saint Luke's Mountain States Tumor Institute - Nampa
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Kootenai Cancer Center
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Kootenai Cancer Clinic
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Alison K. Conlin

Saint Luke's Mountain States Tumor Institute-Twin Falls
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Illinois CancerCare-Bloomington
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Memorial Hospital of Carbondale
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SIH Cancer Institute
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Mount Sinai Hospital Medical Center
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Northwestern University
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University of Illinois
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University of Chicago Comprehensive Cancer Center
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NorthShore University HealthSystem-Evanston Hospital
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NorthShore University HealthSystem-Glenbrook Hospital
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NorthShore University HealthSystem-Highland Park Hospital
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Loyola University Medical Center
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OSF Saint Francis Medical Center
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North Shore Medical Center
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Southern Illinois University School of Medicine
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Reid Health
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University of Kansas Cancer Center
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Cancer Center of Kansas-Kingman
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Olathe Medical Center
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University of Kansas Hospital-Westwood Cancer Center
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Associates In Womens Health
Wichita, KS United States
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Cancer Center of Kansas-Wichita Medical Arts Tower
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Cancer Center of Kansas - Winfield
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Ochsner Health Center-Summa
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Ochsner Medical Center Jefferson
New Orleans, LA United States
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Shreveport, LA United States
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Eastern Maine Medical Center
Bangor, ME United States
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Lafayette Family Cancer Center-EMMC
Brewer, ME United States
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University of Maryland/Greenebaum Cancer Center
Baltimore, MD United States
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Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore, MD United States
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Walter Reed National Military Medical Center
Bethesda, MD United States
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Massachusetts General Hospital Cancer Center
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Dana-Farber Cancer Institute
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Henry Ford Cancer Institute Downriver
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Beaumont Hospital-Dearborn
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Henry Ford Medical Center-Fairlane
Dearborn, MI United States
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Wayne State University/Karmanos Cancer Institute
Detroit, MI United States
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Henry Ford Hospital
Detroit, MI United States
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Green Bay Oncology - Escanaba
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Weisberg Cancer Treatment Center
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William Beaumont Hospital-Grosse Point
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Allegiance Health
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West Michigan Cancer Center
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Henry Ford Medical Center-Columbus
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Pontiac, MI United States
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Lake Huron Medical Center
Port Huron, MI United States
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Michigan Cancer Specialists
Roseville, MI United States
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Oakland Colon and Rectal Association
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Royal Oak, MI United States
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Cape Girardeau, MO United States
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Siteman Cancer Center at West County Hospital
Creve Coeur, MO United States
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Independence, MO United States
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Missouri Baptist Sullivan Hospital
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Nebraska Medicine-Village Pointe
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University of Nebraska Medical Center
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Comprehensive Cancer Centers of Nevada - Henderson
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John A. Ellerton

Nevada Cancer Specialists-Saint Rose
Henderson, NV United States
  Connect »

John A. Ellerton

21st Century Oncology-Henderson
Henderson, NV United States
  Connect »

John A. Ellerton

Comprehensive Cancer Centers of Nevada-Southeast Henderson
Henderson, NV United States
  Connect »

John A. Ellerton

Desert West Surgery
Las Vegas, NV United States
  Connect »

John A. Ellerton

Nevada Cancer Specialists?Oakey
Las Vegas, NV United States
  Connect »

John A. Ellerton

University Medical Center of Southern Nevada
Las Vegas, NV United States
  Connect »

John A. Ellerton

Cancer and Blood Specialists-Shadow
Las Vegas, NV United States
  Connect »

John A. Ellerton

Radiation Oncology Centers of Nevada Central
Las Vegas, NV United States
  Connect »

John A. Ellerton

21st Century Oncology
Las Vegas, NV United States
  Connect »

John A. Ellerton

HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
Las Vegas, NV United States
  Connect »

John A. Ellerton

HealthCare Partners Medical Group Oncology/Hematology-San Martin
Las Vegas, NV United States
  Connect »

John A. Ellerton

Radiation Oncology Centers of Nevada Southeast
Las Vegas, NV United States
  Connect »

Cancer Therapy and Integrative Medicine
Las Vegas, NV United States
  Connect »

John A. Ellerton

21st Century Oncology-Vegas Tenaya
Las Vegas, NV United States
  Connect »

John A. Ellerton

Ann M Wierman MD LTD
Las Vegas, NV United States
  Connect »

John A. Ellerton

Cancer and Blood Specialists-Tenaya
Las Vegas, NV United States
  Connect »

John A. Ellerton

Comprehensive Cancer Centers of Nevada - Northwest
Las Vegas, NV United States
  Connect »

John A. Ellerton

HealthCare Partners Medical Group Oncology/Hematology-Tenaya
Las Vegas, NV United States
  Connect »

John A. Ellerton

Nevada Cancer Specialists-Tenaya
Las Vegas, NV United States
  Connect »

John A. Ellerton

Comprehensive Cancer Centers of Nevada-Summerlin
Las Vegas, NV United States
  Connect »

John A. Ellerton

Summerlin Hospital Medical Center
Las Vegas, NV United States
  Connect »

John A. Ellerton

Las Vegas Cancer Center-Medical Center
Las Vegas, NV United States
  Connect »

John A. Ellerton

21st Century Oncology-Fort Apache
Las Vegas, NV United States
  Connect »

John A. Ellerton

Comprehensive Cancer Centers of Nevada
Las Vegas, NV United States
  Connect »

John A. Ellerton

Nevada Cancer Specialists-Fort Apache
Las Vegas, NV United States
  Connect »

John A. Ellerton

HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
Las Vegas, NV United States
  Connect »

John A. Ellerton

Comprehensive Cancer Centers of Nevada - Central Valley
Las Vegas, NV United States
  Connect »

John A. Ellerton

University Cancer Center
Las Vegas, NV United States
  Connect »

John A. Ellerton

Hope Cancer Care of Nevada-Pahrump
Pahrump, NV United States
  Connect »

John A. Ellerton

Renown Regional Medical Center
Reno, NV United States
  Connect »

John A. Ellerton

Saint Mary's Regional Medical Center
Reno, NV United States
  Connect »

John A. Ellerton

Radiation Oncology Associates
Reno, NV United States
  Connect »

Swaroopa Yerrabothala

Dartmouth Hitchcock Medical Center
Lebanon, NH United States
  Connect »

Dale G. Schaar

Rutgers Cancer Institute of New Jersey
New Brunswick, NJ United States
  Connect »

Montefiore Medical Center-Einstein Campus
Bronx, NY United States
  Connect »

Montefiore Medical Center-Weiler Hospital
Bronx, NY United States
  Connect »

Montefiore Medical Center - Moses Campus
Bronx, NY United States
  Connect »

Roswell Park Cancer Institute
Buffalo, NY United States
  Connect »

Jonathan E. Kolitz

North Shore University Hospital
Manhasset, NY United States
  Connect »

Jonathan E. Kolitz

Long Island Jewish Medical Center
New Hyde Park, NY United States
  Connect »

Paul M. Barr

University of Rochester
Rochester, NY United States
  Connect »

Michael W. Schuster

Stony Brook University Medical Center
Stony Brook, NY United States
  Connect »

Raymond Thertulien

Asheville Hematology-Oncology Associates
Asheville, NC United States
  Connect »

Katarzyna J. Jamieson

UNC Lineberger Comprehensive Cancer Center
Chapel Hill, NC United States
  Connect »

Bayard L. Powell

Wake Forest University Health Sciences
Winston-Salem, NC United States
  Connect »

Howard M. Gross

Indu and Raj Soin Medical Center
Beavercreek, OH United States
  Connect »

Toledo Clinic Cancer Centers-Bowling Green
Bowling Green, OH United States
  Connect »

Howard M. Gross

Dayton Physicians LLC-Miami Valley South
Centerville, OH United States
  Connect »

Howard M. Gross

Miami Valley Hospital South
Centerville, OH United States
  Connect »

Oncology Hematology Care Inc-Eden Park
Cincinnati, OH United States
  Connect »

Oncology Hematology Care Inc-Mercy West
Cincinnati, OH United States
  Connect »

University of Cincinnati/Barrett Cancer Center
Cincinnati, OH United States
  Connect »

Oncology Hematology Care Inc - Anderson
Cincinnati, OH United States
  Connect »

Howard M. Gross

Oncology Hematology Care Inc-Kenwood
Cincinnati, OH United States
  Connect »

Oncology Hematology Care Inc-Blue Ash
Cincinnati, OH United States
  Connect »

Case Western Reserve University
Cleveland, OH United States
  Connect »

Aaron T. Gerds

Cleveland Clinic Foundation
Cleveland, OH United States
  Connect »

Bhavana Bhatnagar

Ohio State University Comprehensive Cancer Center
Columbus, OH United States
  Connect »

Howard M. Gross

Good Samaritan Hospital - Dayton
Dayton, OH United States
  Connect »

Howard M. Gross

Miami Valley Hospital
Dayton, OH United States
  Connect »

Howard M. Gross

Dayton Physicians LLC-Samaritan North
Dayton, OH United States
  Connect »

Oncology Hematology Care Inc-Healthplex
Fairfield, OH United States
  Connect »

Howard M. Gross

Armes Family Cancer Center
Findlay, OH United States
  Connect »

Howard M. Gross

Blanchard Valley Hospital
Findlay, OH United States
  Connect »

Howard M. Gross

Orion Cancer Care
Findlay, OH United States
  Connect »

Howard M. Gross

Atrium Medical Center-Middletown Regional Hospital
Franklin, OH United States
  Connect »

Howard M. Gross

Dayton Physicians LLC-Atrium
Franklin, OH United States
  Connect »

Howard M. Gross

Dayton Physicians LLC-Wayne
Greenville, OH United States
  Connect »

Howard M. Gross

Wayne Hospital
Greenville, OH United States
  Connect »

Howard M. Gross

Greater Dayton Cancer Center
Kettering, OH United States
  Connect »

Howard M. Gross

First Dayton Cancer Care
Kettering, OH United States
  Connect »

Howard M. Gross

Kettering Medical Center
Kettering, OH United States
  Connect »

Lima Memorial Hospital
Lima, OH United States
  Connect »

Toledo Clinic Cancer Centers-Maumee
Maumee, OH United States
  Connect »

Toledo Radiation Oncology at Northwest Ohio Onocolgy Center
Maumee, OH United States
  Connect »

Dayton Physicians LLC-Signal Point
Middletown, OH United States
  Connect »

Saint Charles Hospital
Oregon, OH United States
  Connect »

Toledo Clinic Cancer Centers-Oregon
Oregon, OH United States
  Connect »

Dayton Physicians LLC-Wilson
Sidney, OH United States
  Connect »

Howard M. Gross

Springfield Regional Cancer Center
Springfield, OH United States
  Connect »

Howard M. Gross

Springfield Regional Medical Center
Springfield, OH United States
  Connect »

Mercy Hospital of Tiffin
Tiffin, OH United States
  Connect »

The Toledo Hospital/Toledo Children's Hospital
Toledo, OH United States
  Connect »

Saint Vincent Mercy Medical Center
Toledo, OH United States
  Connect »

University of Toledo
Toledo, OH United States
  Connect »

Toledo Community Hospital Oncology Program CCOP
Toledo, OH United States
  Connect »

Mercy Saint Anne Hospital
Toledo, OH United States
  Connect »

Toledo Clinic Cancer Centers-Toledo
Toledo, OH United States
  Connect »

Howard M. Gross

Dayton Physicians LLC-Upper Valley
Troy, OH United States
  Connect »

Howard M. Gross

Upper Valley Medical Center
Troy, OH United States
  Connect »

Fulton County Health Center
Wauseon, OH United States
  Connect »

University Pointe
West Chester, OH United States
  Connect »

Wright-Patterson Medical Center
Wright-Patterson Air Force Base, OH United States
  Connect »

George B. Selby

University of Oklahoma Health Sciences Center
Oklahoma City, OK United States
  Connect »

Alison K. Conlin

Saint Charles Health System
Bend, OR United States
  Connect »

Alison K. Conlin

Clackamas Radiation Oncology Center
Clackamas, OR United States
  Connect »

Alison K. Conlin

Providence Oncology and Hematology Care Southeast
Clackamas, OR United States
  Connect »

Alison K. Conlin

Bay Area Hospital
Coos Bay, OR United States
  Connect »

Alison K. Conlin

Providence Newberg Medical Center
Newberg, OR United States
  Connect »

Providence Willamette Falls Medical Center
Oregon City, OR United States
  Connect »

Alison K. Conlin

Providence Portland Medical Center
Portland, OR United States
  Connect »

Alison K. Conlin

Providence Saint Vincent Medical Center
Portland, OR United States
  Connect »

Joseph J. Vadakara

Geisinger Medical Center
Danville, PA United States
  Connect »

David F. Claxton

Penn State Milton S Hershey Medical Center
Hershey, PA United States
  Connect »

Selina M. Luger

University of Pennsylvania/Abramson Cancer Center
Philadelphia, PA United States
  Connect »

Neil D. Palmisiano

Thomas Jefferson University Hospital
Philadelphia, PA United States
  Connect »

Fox Chase Cancer Center
Philadelphia, PA United States
  Connect »

University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh, PA United States
  Connect »

Joseph J. Vadakara

Community Medical Center
Scranton, PA United States
  Connect »

AnMed Health Cancer Center
Anderson, SC United States
  Connect »

Jeffrey K. Giguere

Greenville Health System Cancer Institute-Easley
Easley, SC United States
  Connect »

Gibbs Cancer Center-Gaffney
Gaffney, SC United States
  Connect »

Greenville Health System Cancer Institute-Andrews
Greenville, SC United States
  Connect »

Robert D. Siegel

Saint Francis Hospital
Greenville, SC United States
  Connect »

Jeffrey K. Giguere

Greenville Health System Cancer Institute-Butternut
Greenville, SC United States
  Connect »

Jeffrey K. Giguere

Greenville Health System Cancer Institute-Faris
Greenville, SC United States
  Connect »

Jeffrey K. Giguere

Greenville Memorial Hospital
Greenville, SC United States
  Connect »

Robert D. Siegel

Saint Francis Cancer Center
Greenville, SC United States
  Connect »

Jeffrey K. Giguere

Greenville Health System Cancer Institute-Eastside
Greenville, SC United States
  Connect »

Jeffrey K. Giguere

Greenville Health System Cancer Institute-Greer
Greer, SC United States
  Connect »

Gibbs Cancer Center-Pelham
Greer, SC United States
  Connect »

Carolina Blood and Cancer Care Associates PA-Lancaster
Lancaster, SC United States
  Connect »

Carolina Blood and Cancer Care Associates PA
Rock Hill, SC United States
  Connect »

Jeffrey K. Giguere

Greenville Health System Cancer Institute-Seneca
Seneca, SC United States
  Connect »

Spartanburg Medical Center
Spartanburg, SC United States
  Connect »

Jeffrey K. Giguere

Greenville Health System Cancer Institute-Spartanburg
Spartanburg, SC United States
  Connect »

Vanderbilt-Ingram Cancer Center Cool Springs
Franklin, TN United States
  Connect »

Vanderbilt Breast Center at One Hundred Oaks
Nashville, TN United States
  Connect »

Vanderbilt University/Ingram Cancer Center
Nashville, TN United States
  Connect »

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
Houston, TX United States
  Connect »

Ben Taub General Hospital
Houston, TX United States
  Connect »

Julie D. Asch

American Fork Hospital / Huntsman Intermountain Cancer Center
American Fork, UT United States
  Connect »

Julie D. Asch

Sandra L Maxwell Cancer Center
Cedar City, UT United States
  Connect »

Tibor J. Kovacsovics

Farmington Health Center
Farmington, UT United States
  Connect »

Julie D. Asch

Logan Regional Hospital
Logan, UT United States
  Connect »

Julie D. Asch

Intermountain Medical Center
Murray, UT United States
  Connect »

Julie D. Asch

McKay-Dee Hospital Center
Ogden, UT United States
  Connect »

Julie D. Asch

Utah Valley Regional Medical Center
Provo, UT United States
  Connect »

Julie D. Asch

Riverton Hospital
Riverton, UT United States
  Connect »

Julie D. Asch

Dixie Medical Center Regional Cancer Center
Saint George, UT United States
  Connect »

Julie D. Asch

Utah Cancer Specialists-Salt Lake City
Salt Lake City, UT United States
  Connect »

Tibor J. Kovacsovics

Huntsman Cancer Institute/University of Utah
Salt Lake City, UT United States
  Connect »

Julie D. Asch

LDS Hospital
Salt Lake City, UT United States
  Connect »

Tibor J. Kovacsovics

South Jordan Health Center
South Jordan, UT United States
  Connect »

Fredericksburg Oncology Inc
Fredericksburg, VA United States
  Connect »

Danielle A. Shafer

Virginia Commonwealth University/Massey Cancer Center
Richmond, VA United States
  Connect »

Alison K. Conlin

Providence Regional Cancer System-Aberdeen
Aberdeen, WA United States
  Connect »

Cancer Care Center at Island Hospital
Anacortes, WA United States
  Connect »

Swedish Cancer Institute-Eastside Oncology Hematology
Bellevue, WA United States
  Connect »

Alison K. Conlin

PeaceHealth Saint Joseph Medical Center
Bellingham, WA United States
  Connect »

Alison K. Conlin

Providence Regional Cancer System-Centralia
Centralia, WA United States
  Connect »

Alison K. Conlin

Swedish Medical Center-Edmonds
Edmonds, WA United States
  Connect »

Alison K. Conlin

Providence Regional Cancer Partnership
Everett, WA United States
  Connect »

Alison K. Conlin

Swedish Cancer Institute-Issaquah
Issaquah, WA United States
  Connect »

Alison K. Conlin

Kadlec Clinic Hematology and Oncology
Kennewick, WA United States
  Connect »

Alison K. Conlin

Providence Regional Cancer System-Lacey
Lacey, WA United States
  Connect »

Alison K. Conlin

PeaceHealth Saint John Medical Center
Longview, WA United States
  Connect »

Minor and James Medical PLLC
Seattle, WA United States
  Connect »

Alison K. Conlin

Pacific Gynecology Specialists
Seattle, WA United States
  Connect »

Alison K. Conlin

Swedish Medical Center-Ballard Campus
Seattle, WA United States
  Connect »

Alison K. Conlin

Kaiser Permanente Washington
Seattle, WA United States
  Connect »

Alison K. Conlin

Swedish Medical Center-First Hill
Seattle, WA United States
  Connect »

Alison K. Conlin

Swedish Medical Center-Cherry Hill
Seattle, WA United States
  Connect »

Alison K. Conlin

Providence Regional Cancer System-Shelton
Shelton, WA United States
  Connect »

Rockwood Clinic Cancer Treatment Center-Valley
Spokane Valley, WA United States
  Connect »

Rockwood Cancer Treatment Center-DHEC-Downtown
Spokane, WA United States
  Connect »

Evergreen Hematology and Oncology PS
Spokane, WA United States
  Connect »

Rockwood North Cancer Treatment Center
Spokane, WA United States
  Connect »

Alison K. Conlin

PeaceHealth Southwest Medical Center
Vancouver, WA United States
  Connect »

Alison K. Conlin

Providence Saint Mary Regional Cancer Center
Walla Walla, WA United States
  Connect »

North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
Yakima, WA United States
  Connect »

Alison K. Conlin

Providence Regional Cancer System-Yelm
Yelm, WA United States
  Connect »

Chady A. Leon

Marshfield Clinic Cancer Center - Eau Claire
Eau Claire, WI United States
  Connect »

Marshfield Clinic Cancer Center at Sacred Heart
Eau Claire, WI United States
  Connect »

Brian L. Burnette

Green Bay Oncology at Saint Vincent Hospital
Green Bay, WI United States
  Connect »

Brian L. Burnette

Saint Vincent Hospital Cancer Center Green Bay
Green Bay, WI United States
  Connect »

Brian L. Burnette

Green Bay Oncology Limited at Saint Mary's Hospital
Green Bay, WI United States
  Connect »

Brian L. Burnette

Saint Vincent Hospital Cancer Center at Saint Mary's
Green Bay, WI United States
  Connect »

Kurt Oettel

Gundersen Lutheran Medical Center
La Crosse, WI United States
  Connect »

Ryan J. Mattison

University of Wisconsin Hospital and Clinics
Madison, WI United States
  Connect »

Brian L. Burnette

Holy Family Memorial Hospital
Manitowoc, WI United States
  Connect »

Chady A. Leon

Marshfield Clinic
Marshfield, WI United States
  Connect »

Chady A. Leon

Marshfield Medical Center
Marshfield, WI United States
  Connect »

Ehab L. Atallah

Froedtert and the Medical College of Wisconsin
Milwaukee, WI United States
  Connect »

Chady A. Leon

Marshfield Clinic-Minocqua Center
Minocqua, WI United States
  Connect »

Brian L. Burnette

Green Bay Oncology - Oconto Falls
Oconto Falls, WI United States
  Connect »

Chady A. Leon

Marshfield Clinic-Rice Lake Center
Rice Lake, WI United States
  Connect »

Brian L. Burnette

HSHS Saint Nicholas Hospital
Sheboygan, WI United States
  Connect »

Chady A. Leon

Marshfield Clinic Stevens Point Center
Stevens Point, WI United States
  Connect »

Brian L. Burnette

Saint Vincent Hospital Cancer Center at Sturgeon Bay
Sturgeon Bay, WI United States
  Connect »

Brian L. Burnette

Green Bay Oncology - Sturgeon Bay
Sturgeon Bay, WI United States
  Connect »

Chady A. Leon

Marshfield Clinic-Wausau Center
Wausau, WI United States
  Connect »

Chady A. Leon

Marshfield Clinic - Weston Center
Weston, WI United States
  Connect »

Rocky Mountain Oncology
Casper, WY United States
  Connect »

Big Horn Basin Cancer Center
Cody, WY United States
  Connect »

Benjamin T. Marchello

Billings Clinic-Cody
Cody, WY United States
  Connect »

Benjamin T. Marchello

Welch Cancer Center
Sheridan, WY United States
  Connect »

Sita D. Bhella

Kingston Health Sciences Centre
Kingston, ON Canada
  Connect »

Julie Bergeron

CIUSSSEMTL-Hopital Maisonneuve-Rosemont
Montreal, QC Canada
  Connect »

Muhammad Aslam

Allan Blair Cancer Centre
Regina, SK Canada
  Connect »

Jacob M. Rowe

Rambam Medical Center
Haifa, Israel
  Connect »

Jacob M. Rowe

Shaare Zedek Medical Center
Jerusalem, Israel
  Connect »

Andrew P. Dalovisio

Medical Center of Baton Rouge
Baton Rouge, LA United States
  Connect »

Brian L. Burnette

Saint Vincent Hospital Cancer Center at Marinette
Marinette, WI United States
  Connect »

Central Care Cancer Center - Bolivar
Bolivar, MO United States
  Connect »

John A. Ellerton

Huron Medical Center PC
Port Huron, MI United States
  Connect »

Kathleen J. Yost

Bronson Battle Creek
Battle Creek, MI United States
  Connect »

Kathleen J. Yost

Mercy Health Saint Mary's
Grand Rapids, MI United States
  Connect »

Kathleen J. Yost

Spectrum Health at Butterworth Campus
Grand Rapids, MI United States
  Connect »

Kathleen J. Yost

Borgess Medical Center
Kalamazoo, MI United States
  Connect »

Kathleen J. Yost

Bronson Methodist Hospital
Kalamazoo, MI United States
  Connect »

Kathleen J. Yost

Mercy Health Mercy Campus
Muskegon, MI United States
  Connect »

Kathleen J. Yost

Spectrum Health Reed City Hospital
Reed City, MI United States
  Connect »

Kathleen J. Yost

Marie Yeager Cancer Center
Saint Joseph, MI United States
  Connect »

Kathleen J. Yost

Munson Medical Center
Traverse City, MI United States
  Connect »

Kathleen J. Yost

Metro Health Hospital
Wyoming, MI United States
  Connect »

Stephen Couban

QEII Health Sciences Centre/Nova Scotia Health Authority
Halifax, NS Canada
  Connect »

Aaron T. Gerds

Cleveland Clinic-Weston
Weston, FL United States
  Connect »

Joseph J. Merchant

McFarland Clinic PC - Ames
Ames, IA United States
  Connect »

Raymond Thertulien

Park Ridge Health
Hendersonville, NC United States
  Connect »

Kathleen J. Yost

Lakeland Hospital Niles
Niles, MI United States
  Connect »

Kathleen J. Yost

Lakeland Medical Center Saint Joseph
Saint Joseph, MI United States
  Connect »

Bryan A. Faller

Capital Region Southwest Campus
Jefferson City, MO United States
  Connect »

Jonathan E. Kolitz

Northwell Health/Center for Advanced Medicine
Lake Success, NY United States
  Connect »

William A. Hammond

Baptist MD Anderson Cancer Center
Jacksonville, FL United States
  Connect »

Raymond Thertulien

Haywood Infusion Center
Clyde, NC United States
  Connect »

Yasser R. Abou Mourad

Clinical Research Unit at Vancouver Coastal Health Authority
Vancouver, BC Canada
  Connect »

Ishmael A. Jaiyesimi

Beaumont Hospital - Farmington Hills
Farmington Hills, MI United States
  Connect »

Alison K. Conlin

Saint Charles Health System-Redmond
Redmond, OR United States
  Connect »

Madhuri Vusirikala

Parkland Memorial Hospital
Dallas, TX United States
  Connect »

Madhuri Vusirikala

UT Southwestern/Simmons Cancer Center-Dallas
Dallas, TX United States
  Connect »

Alison K. Conlin

PeaceHealth United General Medical Center
Sedro-Woolley, WA United States
  Connect »

Kareem Jamani

Tom Baker Cancer Centre
Calgary, AB Canada
  Connect »

Bryan A. Faller

Cancer Care Specialists of Illinois - Decatur
Decatur, IL United States
  Connect »

Bryan A. Faller

Southwest Illinois Health Services LLP
Swansea, IL United States
  Connect »

Parkview Hospital Randallia
Fort Wayne, IN United States
  Connect »

Steven D. Gore

Smilow Cancer Hospital-Torrington Care Center
Torrington, CT United States
  Connect »

Ascension Saint John Hospital
Detroit, MI United States
  Connect »

ProMedica Flower Hospital
Sylvania, OH United States
  Connect »

Uzair B. Chaudhary

University Oncology Associates
Clovis, CA United States
  Connect »

Mark B. Geyer

Memorial Sloan Kettering Basking Ridge
Basking Ridge, NJ United States
  Connect »

Mark B. Geyer

Memorial Sloan Kettering Monmouth
Middletown, NJ United States
  Connect »

Mark B. Geyer

Memorial Sloan Kettering Bergen
Montvale, NJ United States
  Connect »

Mark B. Geyer

Memorial Sloan Kettering Commack
Commack, NY United States
  Connect »

Mark B. Geyer

Memorial Sloan Kettering Westchester
Harrison, NY United States
  Connect »

Mark B. Geyer

Memorial Sloan Kettering Cancer Center
New York, NY United States
  Connect »

Mark B. Geyer

Memorial Sloan Kettering Rockville Centre
Rockville Centre, NY United States
  Connect »

Uzair B. Chaudhary

California Cancer Center - Fresno
Fresno, CA United States
  Connect »

Howard M. Gross

Miami Valley Hospital North
Dayton, OH United States
  Connect »

Recruitment Status: Open


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