Myocardial Protection Effect of Simvastatin Undergoing Cardiac Surgery

  • End date
    Dec 27, 2024
  • participants needed
  • sponsor
    Sun Yat-sen University
Updated on 27 January 2021
coronary artery disease
heart disease
bypass graft
heart surgery
cardiopulmonary bypass
valvular disease
cholesterol measurement
hmg-coa reductase inhibitors


Statins have been used to low cholesterol to prevent and treat coronary artery diseases. It was also reported that statins could protect endothelial function and cardiac function during coronary artery bypass graft. The investigators recent found simvastatin reduced myocardial injury during noncoronary artery cardiac surgery in single medical center. The investigators further investigate that whether simvastatin can protect myocardium during noncoronary artery cardiac surgery with cardiopulmonary bypass and improve cardiac function with long term use postoperatively in two medical centers.

Condition Heart disease, Heart disease, Cardiac Disease, VALVULAR HEART DISEASE, Heart Valve Disease, Congenital Heart Disease, Heart Valve Disease, Cardiac Disease
Treatment Simvastatin
Clinical Study IdentifierNCT01653223
SponsorSun Yat-sen University
Last Modified on27 January 2021


Yes No Not Sure

Inclusion Criteria

More than 18-year-old
Congenital heart disease(not complex)
Isolated heart valve disease

Exclusion Criteria

Coronary artery disease
Allergy for statins
Poor liver function,Hepatitis
Gestation women and Breast-feeding women
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