Familial Dysglobulinemia

  • STATUS
    Recruiting
  • End date
    Feb 25, 2025
  • participants needed
    3000
  • sponsor
    Hospices Civils de Lyon
Updated on 25 January 2021
Investigator
Charles DUMONTET, PU-PH
Primary Contact
Service d'h matologie Clinique (0.8 mi away) Contact
+46 other location

Summary

Multiple Myeloma (MM) is a malignant proliferation of monoclonal plasma cells. Myeloma accounts for almost 14% of all hematologic cancers and is essentially incurable. Myeloma commonly evolves from a precursor disease, Monoclonal gammopathy of undetermined significance (MGUS). Despite intensive study, the etiology of MGUS and myeloma are unknown and no lifestyle or environmental exposure factors have been identified that are consistently linked to increased risk of MM, MGUS or the transition between the two.

The overall goal is to identify risk genes for dysglobulinemia, and more specifically Multiple Myeloma. This will involve the conservation of cells in a bank and genetic sequencing on samples obtained from families with at least two cases of dysglobulinemia. Material used for sequencing is likely to include fresh peripheral blood cells or lymphoblastoid lines established from peripheral blood lymphocytes of patients.

Details
Condition Dysglobulinemia
Treatment Genetic analysis of peripheral blood samples
Clinical Study IdentifierNCT02853214
SponsorHospices Civils de Lyon
Last Modified on25 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

cases per family at least
case alive at least
biological material available for 1 case at least
Patients give their informed consent
attached to the French Health protection service

Exclusion Criteria

Age under 18
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