Does Timing of VT Ablation Affect Prognosis in Patients With an Implantable Cardioverter-defibrillator?

  • STATUS
    Recruiting
  • participants needed
    590
  • sponsor
    IRCCS San Raffaele
Updated on 4 October 2022
shock
secondary prevention
sudden cardiac death

Summary

The purpose of this study is to assess whether the burden of untreated non-sustained ventricular tachycardias (VTs), or episodes treated with anti-tachycardia pacing, correlates with appropriate implantable cardiac defibrillator (ICD) shock therapies and to evaluate if the timing of radiofrequency VT ablation affects the prognosis of ICD recipients.

Description

Enrolled patients will remain in a first phase of the study until the first appropriate ICD shock will be delivered.

The objective of this first stage is to assess whether the burden of untreated non sustained VTs or episodes treated with anti-tachycardia pacing is predictive of appropriate ICD shocks.

The second phase of the study will start after the first appropriate ICD shock delivered for VT.

Patients will be then randomized to immediate VT ablation or to standard treatment, meaning waiting until next arrhythmic storm to perform a VT ablation procedure.

The objective of this phase is compare the rate of worsening heart failure hospitalizations and deaths from any cause between the two groups.

Details
Condition Tachycardia, Fast Heart Rate (Tachycardia), Ventricular tachycardia, Fast Heart Rate (Tachycardia)
Treatment Immediate radiofrequency ablation of ventricular tachycardia, Radiofrequency ablation of ventricular tachycardia
Clinical Study IdentifierNCT01547208
SponsorIRCCS San Raffaele
Last Modified on4 October 2022

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