Investigation of Dysynchrony in Patients With Pulmonary Hypertension
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- STATUS
- Recruiting
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- End date
- Dec 23, 2025
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- participants needed
- 100
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- sponsor
- Stanford University
Summary
The purpose of the study is to determine whether patients with pulmonary hypertension (PH) have dysynchrony, and if so whether it is electrical or mechanical. Once this has been determined, during a catheterization the investigators will test if pacing the heart improves blood circulation.
Description
This is a two part study of ventricular dysynchrony in patients with pulmonary hypertension. The first part is an observational study, reviewing routinely obtained clinical information (such as echocardiograms) to assess whether patients with pulmonary hypertension have electrical or mechanical dysynchrony. If so, we will proceed to the second part of the study which will assess whether temporarily pacing the right ventricle, during a clinically indicated catheterization can acutely improve hemodynamics. We will also gather control data for phase 1 from clinically indicated echos and ECG's in patients with ASD's (RV volume load) and in patients who are evaluated for an innocent murmur ( Nl heart). We hope to learn whether patients with pulmonary hypertension, and compromised right ventricles have electrical and mechanical dysnchrony. If this is true, it is theoretically possible that resynchronization (pacing) of the right ventricle could improve hemodynamics, symptoms and long term outcomes.
Details
| Condition | Mental Disability, Testotoxikose, Nerve Injury, Recurrent Pregnancy Loss, Cancer Prevention, Pelvic Adhesions, Gambling Problems, Functional Dyspepsia, Memory Problems, Low Testosterone, Dental Filling, Severe Premenstrual Symptom, Abdominal Surgery, Pulmonary Arterial Hypertension, Spinocerebellar Disorders, Joint Injuries, Chronic Pelvic Pain, Surviving Abuse, Pulmonary Hypertension, Cancer Treatment, Habit Reversal, Open Heart Surgery, Myopic Macular Degeneration, Effects of Chemotherapy, Stasis Dermatitis, Anemic Cancer, Serial Evaluation of Ductal Epithelium, Chronic Renal Anemia, Partial Medial Meniscectomy, Indikation: Diabetes - Typ II, Late Infantile Neuronal Ceroid Lipfuscinsosis, Catheter Complications, Pseudobulbar Affect, Complicated Grief, Renal Anemia, Infantile Fibrosarcoma, Spine Athroplasty, Primary Insulin Hypersecretion |
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| Treatment | Catheterization Pacing |
| Clinical Study Identifier | NCT01571700 |
| Sponsor | Stanford University |
| Last Modified on | 23 September 2021 |
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