Understanding Pain Perception in Osteoarthritis

  • STATUS
    Recruiting
  • days left to enroll
    86
  • participants needed
    250
  • sponsor
    St George's, University of London
Updated on 26 January 2021
steroidal anti-inflammatory drugs
osteoarthritis
x-rays
total knee replacement
knee pain
knee surgery
arthralgia
osteoarthritis of knee
joint replacement

Summary

Osteoarthritis (OA)is a painful and disabling disease, predicted to be the fourth largest cause of disability worldwide by 2020. It commonly affects the hip or knee ultimately resulting in total joint replacement. In order to assess disease progression and plan surgery, x-rays are taken as part of routine practice. However x-rays provide limited information about formation of substructures and changes occurring during progression of disease. The proposed study aims to invite patients with OA of the hip or knee to participate in detailed examinations of their pain and their painful joint through interviews, blood and urine samples taken, MRI magnetic resonance imaging)and donating their waste tissue after joint surgery (all of old joint). Informed patient consent will be sought in all cases.

Description

The patient will be asked for permission for a clinician to access their notes for information relevant to the research, including full medical history, their sex and date of birth. Tissue obtained from joint replacement surgery at St. George's Hospital and transferred to St.George's, University of London where it will be prepared for various experiments including looking at the genes and proteins in people with osteoarthritis. The blood and urine samples will also be taken to St. George's, University of London, and prepared for studies on the genes and proteins in people with osteoarthritis. All samples provided will be anonymised with no patient details on the samples and stored in locked freezers, in locked labs. at St.George's, University of London.

Details
Condition Pain, Post-Surgical Pain, Pain (Pediatric), Pain, Arthritis, Arthritis and Arthritic Pain, Arthritis and Arthritic Pain (Pediatric), Acute Pain Service, Osteoarthritis, Osteoarthritis, Arthritis and Arthritic Pain, Post-Surgical Pain, Pain (Pediatric), Arthritis and Arthritic Pain (Pediatric), degenerative arthritis, ache
Treatment Joint replacement surgery
Clinical Study IdentifierNCT02603939
SponsorSt George's, University of London
Last Modified on26 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Inclusion Criteria for OA patients
Study participant will be recruited from rheumatology outpatient clinics and
primary care
fulfilling the American College of Rheumatology (ACR) criteria for the diagnosis of knee osteoarthritis
male or female
symptomatic knee pain
on usual care for knee osteoarthritis including paracetamol and/or non-steroidal anti-inflammatory drugs
participants between 35 and 90 who will be undergoing knee replacement surgery or arthroscopy for osteoarthritis or knee surgery for fractured tibia/femur/fibula with osteoarthritis
Inclusion criteria for Early OA Patients
Study participant will be recruited from rheumatology outpatient clinics and
primary care
fulfilling the American College of Rheumatology (ACR) criteria for the diagnosis of knee osteoarthritis
male or female
symptomatic knee pain
on usual care for knee osteoarthritis including paracetamol and/or non-steroidal anti-inflammatory drugs
Participants between 35 and 90 who have osteoarthritis but will not be undergoing knee surgery
Inclusion criteria for Healthy control subjects
Participants aged between 35 and 90 who do not have knee pain or osteoarthritis as a comparator group
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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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