Last updated on February 2018

Optimal Treatment on Hepatocellular Carcinoma (HCC) With Cirrhotic Portal Hypertension

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: HEPATOCELLULAR CARCINOMA | Cirrhotic Portal Hypertension
  • Age: Between 18 - 65 Years
  • Gender: Male or Female

Inclusion Criteria:

  • Diagnosis of hepatocellular carcinoma patients, in accordance with HCC Professional Committee of the Chinese Anti-Cancer Association 2001 "Clinical Diagnosis of Primary Liver Cancer and Staging Criteria"
  • solitary tumor 5cm, or three or fewer lesions none 3cmAs Milan criteria
  • History of hepatitis B or HBsAg positive
  • Cirrhosis and portal hypertension
  • No treatment on liver cancer before
  • KPS score 70
  • The age of 18 to 65 years
  • Child-Pugh A or B (Class B, scoring no more than 7 points)
  • Baseline laboratory test comply with the following criteria:
  • White blood cell 1.0109/L
  • Platelet 25109/L
  • Hemoglobin 80g/L
  • Serum ALT,AST 3upper limit of normal (ULN)
  • Serum creatinine 1.5 ULN
  • INR<1.5, or prothrombin time <ULN +4 sec
  • Albumin 30g/L
  • Total bilirubin 34mmol/L
  • Informed consent with signature and time
  • Good patient compliance
  • The surgical group patients received radical hepatectomy. Radical surgery is defined as: complete resection of visible tumor, R0 resection margins, and also including:
  • The number of tumors is less than 3
  • No tumor thrombus found in major branch of the portal veins, hepatics, inferior vena cava or bile duct
  • No hepatic hilar lymph node metastasis
  • No extrahepatic metastasis

Exclusion Criteria:

  • extrahepatic metastasis; With metastasis in major branch of portal vein, hepatic vein
  • History of hepatitis C or HCV-Ab positive
  • Pugh Child-Pugh C, or with massive ascites or had a history of hepatic encephalopathy, or Upper digestive tract bleeding
  • Poor physical condition or cachexia
  • During the past 12 months just before the study, there had been any of the following: myocardial infarction, severe/unstable angina, coronary artery bypass graft surgery, congestive heart failure, cerebrovascular accident (including transient ischemic attack), pulmonary embolism; arrhythmia according to the NCI-CTCAE grade 2, QTc interval extension (male> 450 ms, female> 470 ms);
  • Renal insufficiency, need peritoneal dialysis or hemodialysis
  • Serious dysfunction of other organs
  • History of second primary malignant tumors
  • Known or new evidence of brain or leptomeningeal disease
  • Hemophilia or bleeding tendency, and are taking therapeutic doses of coumarin derivative anticoagulant therapy drugs
  • Pregnant or lactation, all female patients with childbearing potential must have a pregnancy test (serum or urine) within 7 days after enrollment,and the result is negative
  • History of organ transplantation
  • Known HIV infection
  • With any other serious acute and chronic physical or mental disease or abnormal laboratory tests, which are likely to increase risks or interfere with the interpretation of the results, or researchers believe that patients are not suitable for enrollment

Recruitment Status: Open

Brief Description Eligibility Contact Research Team

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