Metabolic Responses to Bariatric Surgery

  • End date
    Apr 26, 2025
  • participants needed
  • sponsor
    University of California, Davis
Updated on 26 March 2022
type 2 diabetes mellitus
bariatric surgery


Research the genetic and biomechanical markers of human adipose tissue on patients with morbid obesity. Additional tissue/fluid collection is also gathered during the time of surgery.


Study participation by invitation after complete pre-surgical work up at UC Davis Health System. Patients will be invited to participate if they meet all inclusion criteria's after completing all necessary clinical visits including lab studies, counseling, and participation in educational programs. During the pre-operative visit patients interested in participation will complete all necessary consent documentation. Pre-operative labs (blood and urine) will be collected along with additional blood, urine, and fecal samples will be collected pre-operatively. During surgery (Roux-en-Y Gastric Bypass surgeries only) tissue collection will include subcutaneous & omental fat, jejunum, and liver biopsy. Post surgery patient will be observed for weight loss and resolution of co-morbidities. At designated times post surgery when lab studies are ordered additional blood/urine samples will be collected and analyzed.

Condition Morbid Obesity
Treatment Surgery
Clinical Study IdentifierNCT02024542
SponsorUniversity of California, Davis
Last Modified on26 March 2022


Yes No Not Sure

Inclusion Criteria

Meet NIH Criteria for Bariatric Surgery
Between the Age of 18-55
Dyslipidemia controlled with medication
Impaired glucose metabolism or type 2 diabetes

Exclusion Criteria

Uncontrolled Metabolic syndrome (uncontrolled diabetes, htn, dyslipidemia), one or all conditions
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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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