Autologous and Allogeneic Whole Cell Cancer Vaccine for Metastatic Tumors

  • days left to enroll
  • participants needed
  • sponsor
    Hadassah Medical Organization
Updated on 23 January 2021
neutrophil count
tumor cells
cancer chemotherapy
cancer vaccine


This study is based on the finding that tumor cells that are grown in the laboratory can be modified in such a way that, when injected to the patient, they will stimulate his/her immune response. This approach will be evaluated in patients with melanoma and colorectal, gastric, ovarian, breast, lung and kidney epithelial cancer. Tumor cells grown in the laboratory will be modified to make them stimulatory to the immune system, irradiated to kill them, and injected to the patient eight times at two-week intervals. This protocol is expected to prolong survival of metastatic cancer patients.

Condition Pulmonary Disease, urinary tract neoplasm, Ovarian disorder, Colorectal Cancer, Malignant neoplasm of kidney, Rectal disorder, Nephropathy, Breast Cancer, Ovarian Cancer, melanoma, Lung Neoplasm, skin cancer, Gastropathy, Gastric Cancer, Bronchial Neoplasm, Stomach Discomfort, Metastatic Melanoma, Kidney Disease (Pediatric), Colon Cancer Screening, Rectal Disorders, Colon cancer; rectal cancer, Ovarian Function, Breast Cancer Diagnosis, Gastric Carcinoma, Recurrent Ovarian Cancer, Kidney Cancer, Lung Cancer, Malignant Melanoma, Kidney Disease, Lung Disease, Stomach Cancer, Renal Cancer, Urologic Cancer, breast carcinoma, colorectal neoplasm, ovarian carcinomas, cancer, ovarian, cancer ovarian, cancer of the ovary, gastric cancers, cancer, breast, colorectal cancers, ovarian tumors, cancer, renal, cancer, colorectal, colorectal tumor, tumors, colorectal, carcinoma lung, lung carcinoma
Treatment Autologous or Allogeneic tumor cells
Clinical Study IdentifierNCT00722228
SponsorHadassah Medical Organization
Last Modified on23 January 2021


Yes No Not Sure

Inclusion Criteria

One of the following metastatic cancers: Melanoma, breast, ovary, colorectal, gastric, lung or kidney
Above 18 years of age
Failure of at least one chemotherapy protocol
Clinical performance status of ECOG 0,1
Absolute neutrophil count greater than 1000/mm3
Serum ALT/AST less than three times the upper limit of normal
Serum creatinine less than or equal to 1.6 mg/dl
Must be able to understand and sign the Informed Consent document

Exclusion Criteria

Below 18 years of age
Women who are pregnant
Life expectancy of less than three months
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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