Proteomics and Radiomics Research of Breast Cancer Markers in Tissue, Interstitial Fluid and Serum

  • STATUS
    Recruiting
  • End date
    Apr 3, 2025
  • participants needed
    300
  • sponsor
    University of Pittsburgh
Updated on 3 May 2022
breast carcinoma
invasive breast cancer
mastectomy
core needle biopsy

Summary

The current study is a case control study involving comparisons of tissue interstitial fluid from breast cancer and adjacent non-cancerous tissue as well as that from benign breast lesion and its adjacent non-diseased tissue for a distinguishable breast cancer profile. The purpose of this research is to collect fresh breast nodule/cancer and surrounding non-cancerous tissue for proteomic studies of the interstitial fluid to identify a profile distinguishing breast cancer which will also permit future research on stored interstitial fluid, blood or tissue samples. Specific markers identified from interstitial fluid study will be investigated in blood samples to develop serum markers for breast cancer diagnosis and prognosis. Additionally, we will perform both prospective and retrospective research on breast cancer involving clinical, demographic, epidemiologic information, treatment, follow-up and outcomes on breast nodule/cancer cases collected.

Details
Condition Breast Cancer
Clinical Study IdentifierNCT01042548
SponsorUniversity of Pittsburgh
Last Modified on3 May 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

All subjects ≥ 18 years of age undergoing surgery for indeterminate breast nodules, breast tissue reduction, prophylactic mastectomy, and all subjects with newly diagnosed invasive breast cancer will be eligible to participate. If invasive breast cancer or suspicion of invasive breast cancer, target lesion must measure ≥ 1.0 cm on breast imaging before core biopsy

Exclusion Criteria

Anyone < 18 years of age
Multiple synchronous primary malignancies from different organ systems
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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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