Cholesterol and Antioxidant Treatment in Patients With Smith-Lemli-Opitz Syndrome (SLOS)

  • STATUS
    Recruiting
  • End date
    Dec 26, 2025
  • participants needed
    100
  • sponsor
    University of Colorado, Denver
Updated on 26 January 2021
anesthesia
antioxidants
retinopathy
cholesterol level
audiometry
electroretinogram

Summary

Patients with biochemically confirmed SLOS are being treated with cholesterol supplementation and antioxidant medication. They are carefully monitored with visits to clinic, laboratory testing including cholesterol and 7-dehydrocholesterol levels, vitamin levels, blood counts and liver and kidney function. On an annual basis, the patients undergo a series of tests under anesthesia, including electroretinogram (ERG), brainstem audiometry (ABR), and ophthalmologic exam under anesthesia to follow pigmentary retinopathy.

Description

Smith-Lemli-Opitz Syndrome (SLOS) is an autosomal recessive disorder caused by a metabolic error in the final step of cholesterol biosynthesis, leading to cholesterol deficiency and accumulation of the cholesterol precursor, 7-dehydrocholesterol.Patients with SLOS display complex medical problems including growth failure, intellectual disability, behavioral disorders, progressive retinal dystrophy, hearing loss and photosensitivity. Dr Elias was one of the original geneticists who discovered the cause of this disorder in 1994, and ever since has been treating SLOS patients with cholesterol supplementation. In 2008, a second medication called AquADEKS, a mixture of vitamins and other compounds with antioxidant properties was added to the treatment regimen. AquADEKS has since been replaced with a comparable medication named DEKAS plus.The purpose of the DEKAS plus is to allow treatment with antioxidant medications in an effort to prevent retinal degeneration, hearing and skin problems associated with SLOS.

This protocol has been approved by the Colorado Multiple Institutional Review Board and supported by the Clinical Translational Research Center (CTRC) since 2001. The following updated information is available about the protocol:

  1. recent research has revealed that oxysterols are toxic compounds made from the cholesterol precursor, 7-dehydrocholesterol. These oxysterol compounds are severely neurotoxic and toxic to the retina, and treatment with antioxidants may help lower their levels, resulting in slowing of retinal deterioration. Testing of oxysterol levels in patients with SLOS is now ongoing, in collaboration with a laboratory at University of Washington in Seattle (Dr Libin Xu). It is hoped that testing of oxysterol levels in blood may help provide more updated info to help guide treatment.

Details
Condition Deafness, Smith-Lemli-Opitz Syndrome, Dyslipidemia, Retinitis Pigmentosa, Hearing Loss, Auditory Loss and Deafness, Hearing Impairment, rod-cone dystrophy, decreased hearing, hard of hearing, hypoacusis
Treatment Antioxidants, Cholesterol, Cholesterol
Clinical Study IdentifierNCT01773278
SponsorUniversity of Colorado, Denver
Last Modified on26 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Clinical diagnosis of Smith-Lemli-Opitz Syndrome
Elevated levels of 7-dehydrocholesterol and 8-dehydrocholesterol
Must be able to travel to Children's Hospital Colorado annually
Must have insurance coverage for ERG/ABR studies

Exclusion Criteria

absence of detectable 7-dehydrocholesterol/8-dehydrocholesterol
allergy to Antioxidant medication
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