Methylphenidate in Adults With Attention Deficit/Hyperactivity Disorder

  • STATUS
    Recruiting
  • End date
    Dec 21, 2032
  • participants needed
    600
  • sponsor
    Hospital de Clinicas de Porto Alegre
Updated on 21 January 2021
psychiatric disorder
methylphenidate
attention deficit disorder

Summary

Methylphenidate (MPH) is the first-line pharmacological treatment for adults with Attention-Deficit/Hyperactivity Disorder (ADHD). Nevertheless, there is considerable interindividual variability regarding the dose required, tolerability and response rates to MPH. The aim of this study is to address the clinical and genetic predictors of MPH treatment outcomes in ADHD.

Description

Methylphenidate (MPH) is the most prescribed psychostimulant for children and adults with Attention-Deficit/Hyperactivity Disorder (ADHD). Meta-analyses and systematic reviews have shown that MPH is safe and efficacious in attenuating the core symptoms of ADHD, promoting overall clinical improvement. However, many patients still do not show an appropriate clinical response to the MPH treatment and there is considerable interindividual variability regarding the dose required, tolerability and response rates to MPH. Therefore, it is essential to address the clinical and genetic predictors of MPH treatment outcomes in ADHD.

Details
Condition Oppositional Defiant Disorder, Oppositional Defiant Disorder (ODD), Attention deficit hyperactivity disorder, Attention Deficit/Hyperactivity Disorder (ADHD - Pediatric), Attention Deficit/Hyperactivity Disorder (ADHD - Adults), Family Medicine-ADHD Pediatrics, Attention Deficit/Hyperactivity Disorder (ADHD - Adults), Attention Deficit/Hyperactivity Disorder (ADHD - Pediatric), Oppositional Defiant Disorder (ODD), Family Medicine-ADHD Pediatrics, adhd
Treatment Immediate-release Methylphenidate
Clinical Study IdentifierNCT02951754
SponsorHospital de Clinicas de Porto Alegre
Last Modified on21 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

White Brazilian of European descent
Fulfillment of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, (DSM-IV) diagnostic criteria for ADHD
Eligibility to immediate-release MPH (IR-MPH) treatment

Exclusion Criteria

Contraindication for IR-MPH use
Current stimulant treatment
Evidence of a clinically significant neurological disease that might affect cognition (e.g., delirium, dementia, epilepsy, head trauma, and multiple sclerosis)
Current or past history of psychosis
Estimated intelligence quotient score lower than 70
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