Last updated on February 2018

Comparison of Low and Intermediate Dose Low-molecular-weight Heparin to Prevent Recurrent Venous Thromboembolism in Pregnancy


Brief description of study

This is a randomized-controlled open-label trial comparing two different doses of low-molecular-weight heparin (LMWH) in pregnant patients with a history of previous venous thromboembolism (VTE). Both doses are recommended doses in the 2012 guidelines of the American College of Chest Physicians (ACCP), but it is not known which dose is more efficacious in preventing recurrent venous thromboembolism in pregnancy.

Patients enter the study and will be randomized as soon as a home test confirms pregnancy. LMWH will be administered until 6 weeks postpartum. Follow-up will continue until 3 months postpartum. Patients will be recruited by their treating physician, either an obstetrician or internist.

Clinical Study Identifier: NCT01828697

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KU Leuven

Leuven, Belgium
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Jeroen Bosch Ziekenhuis

's-Hertogenbosch, Netherlands
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Flevoziekenhuis

Almere, Netherlands
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OLVG

Amsterdam, Netherlands
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SLAZ

Amsterdam, Netherlands
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VU medical center

Amsterdam, Netherlands
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Gelre Ziekenhuizen

Apeldoorn, Netherlands
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Rijnstate hospital

Arnhem, Netherlands
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Bronovo ziekenhuis

Den Haag, Netherlands
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HAGA ziekenhuis

Den Haag, Netherlands
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Deventer Ziekenhuis

Deventer, Netherlands
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Slingeland

Doetinchem, Netherlands
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Albert Schweitzer

Dordrecht, Netherlands
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Martini Ziekenhuis

Groningen, Netherlands
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UMCG

Groningen, Netherlands
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Kennemer Gasthuis

Haarlem, Netherlands
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Atrium MC

Heerlen, Netherlands
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MC Leeuwarden

Leeuwarden, Netherlands
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LUMC

Leiden, Netherlands
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MUMC

Maastricht, Netherlands
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St. Radboud UMC

Nijmegen, Netherlands
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Erasmus MC

Rotterdam, Netherlands
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TweeSteden

Tilburg, Netherlands
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Diakonessen Utrecht

Utrecht, Netherlands
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UMCU

Utrecht, Netherlands
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M xima MC

Veldhoven, Netherlands
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Recruitment Status: Open


Brief Description Eligibility Contact Research Team


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