Last updated on September 2018

Randomized Trial to Assess PO Versus IV Antibiotics


Brief description of study

The goal of this study is to evaluate the effect of treatment of post-op wound infection in long bones after fracture fixation or joint fusion and either: (Group 1) operative debridement and PO antibiotic treatment for 6 weeks; or (Group 2) operative debridement and IV antibiotics for 6 weeks.

Primary Hypothesis: The rate of treatment failure by one year in Group 1 will be non-inferior to the rate in Group 2. Treatment failure is defined as wound problems that require surgery >2 weeks after initial debridement, infection recurrence, infection with a new pathogen, joint erosion, implant failure, medical problems related to the treatment administration which necessitates a switch from one arm to the other.

Detailed Study Description

Not provided here. Details listed above.

Clinical Study Identifier: NCT01714596

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University of Miami Ryder Trauma Center

Miami, FL United States
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