The Antiviral Therapy in Pregnant Women to Reduce Mother-to-infant Transmission of Hepatitis B Virus-drug Test

  • STATUS
    Recruiting
  • End date
    Dec 27, 2021
  • participants needed
    120
  • sponsor
    National Taiwan University Hospital
Updated on 27 January 2021

Summary

Since the implementation of universal vaccination in 1984, the chronic HBV carier rate in our general population reduced from 15-20%, down to < 1% in the post-vaccination population. However, children born to HBeAg positive mothers still may be infected with HBV despite immunization. To further reducing the HBV infection in our people, strategies in reducing infection rate in this high risk group are mandatory. Previous small scale studies using lamivudine treatment in pregnant woman in the third trimester has proved effective in reducing children infection rate. The aims of the present study are to conduct a clinical trial in using Tenofovir (category B) to reduce mother-to-infant transmission, and to monitor the hepaitits B viral status and mother hepatitis occurrence. The clinical trials will screen cases of HBsAg positive pregnant women aged 20 to 40 years at gestational at 20-32 weeks. They will be tested for HBsAg and HBeAg. In whom both markers are positive, HBV viral load will be tested. An estimated 180 pregnant women with high HBV viral load (>10^8 copies/mL) will be recruited in the study; including 80-100 subjects treated with Tenofovir 300 mg daily starting from 30-32 weeks of gestation (3rd trimester) and continued to 1 month after delivery; and 80-100 pregnant women are enrolled as controls with no drug given to the mother. The newborn babies are given with HBIG within 24 hours after delivery, and HBV vaccines at 0, 1 and 6 months. Maternal complete blood count (CBC) data tested in the first prenatal examination will be recorded. Plasma ASTALT levels and HBV DNA are tested before Tenofovir treatment, 1 month after treatment, at the time of delivery, and at 1, 2, 4 and 6 months after delivery. HBsAgHBeAganti-HBs and ASTALT are tested in the children at day 1, 6 moths and 1 year after birth. The primary outcome is reduction of the HBsAg carrier rate of the children at 6 months of age. The secondary outcome is HBsAg carrier rate of the children at 12 months of age, the change of liver function, HBeAg, and viral load in pregnant mother after treatment.

A follow-up study for investigating safety of mothers and children that has been exposed to maternal tenofovir disoproxil fumarate (TDF) during pregnancy in reducing mother-to-infant hepatitis B virus (HBV) transmissions is conducted. The follow-up study included mother-children pairs 2-4 years after delivery of the children.

Details
Condition Hepatitis B Virus Infection, Pregnancy, Hepatitis B Virus Infection, Pregnancy, Hepatitis B Virus Infection, Pregnancy, Hepatitis B Virus Infection, Pregnancy, Hepatitis B Virus Infection, Pregnancy, Hepatitis B Virus Infection, Pregnancy, Hepatitis B Virus Infection, Pregnancy
Treatment antiviral therapy
Clinical Study IdentifierNCT01312012
SponsorNational Taiwan University Hospital
Last Modified on27 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Is your age between 20 yrs and 40 yrs?
Are you female?
Do you have Hepatitis B Virus Infection, Pregnancy?
Do you have any of these conditions: Do you have Hepatitis B Virus Infection, Pregnancy??
Do you have any of these conditions: Do you have Hepatitis B Virus Infection, Pregnancy??
Do you have any of these conditions: Do you have Hepatitis B Virus Infection, Pregnancy??
pregnant women in 30 to 32 weeks of gestation, with positive HBsAg and HBeAg,serum viral load above 8log10 copies per mL

Exclusion Criteria

major systemic disease
Pregnant woman with infection of human immunodeficiency virus or hepatitis C virus
Pregnant woman is receiving any drug with antiviral activity or any form of drug therapy for hepatitis B virus
Pregnant woman whose ultrasonographic examination reveals congenital anomaly of the fetus
Pregnant woman whose amniocentesis reveals any genetic abnormality
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