Immune Disorder HSCT Protocol
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- STATUS
- Recruiting
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- End date
- Mar 11, 2024
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- participants needed
- 20
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- sponsor
- Washington University School of Medicine
Summary
This study hypothesizes that a reduced intensity immunosuppressive preparative regimen will establish engraftment of donor hematopoietic cells with acceptable early and delayed toxicity in patients with immune function disorders. A regimen that maximizes host immune suppression is expected to reduce graft rejection and optimize donor cell engraftment.
Details
| Condition | Immune Deficiency Disorders, Severe Combined Immunodeficiency, Chronic Granulomatous Disease, X-linked Agammaglobulinemia, Wiskott-Aldrich Syndrome, Hyper-IgM, DiGeorge Syndrome, Chediak-Higashi Syndrome, Common Variable Immune Deficiency, Immune Dysregulatory Disorders, Hemophagocytic Lymphohistiocytosis, IPEX, Autoimmune Lymphoproliferative Syndrome, X-linked Lymphoproliferative Syndrome |
|---|---|
| Treatment | Transplant preparative regimen of alemtuzumab, fludarabine, thiotepa, and melphalan |
| Clinical Study Identifier | NCT01821781 |
| Sponsor | Washington University School of Medicine |
| Last Modified on | 11 May 2022 |
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