Opsoclonus Myoclonus Syndrome/Dancing Eye Syndrome (OMS/DES) in Children With and Without Neuroblastoma (NBpos and NBneg)Opsoclonus Myoclonus Syndrome/Dancing Eye Syndrome (OMS/DES) in Children With and Without Neuroblastoma (NBpos and NBneg)

  • STATUS
    Not Recruiting
  • End date
    Apr 17, 2031
  • participants needed
    100
  • sponsor
    Institut Curie
Updated on 24 January 2021
Investigator
Roman ROUZIER, PHD
Primary Contact
Chu D'Estaing (0.0 mi away) Contact
+35 other location
cyclophosphamide

Summary

The OMS/DES study is a multinational European Trial for Children with the Opsoclonus Myoclonus Syndrome / Dancing Eye Syndrome.

This trial brought on the way by specialists of the EPNS (European Paediatric Neurology Society), the GPOH (Gesellschaft fr Pdiatrische Hematologic und Oncologie) and the SIOPEN (SIOP (International Society Oncology Pediatric) Europe Neuroblastoma).

This protocol will investigate an escalating treatment schedule starting with a corticosteroid standard treatment with dexamethasone pulses (first step), which is followed, if response has been inadequate after 3 months of treatment, by the addition of CP (second step) and, if still no sufficient improvement, by the replacement of CP by Rituximab (third step). Treatment intensification is decided on the basis of standardized scoring of OMS/DES severity.

Details
Condition Opsoclonus-Myoclonus Syndrome, Neuroblastoma
Treatment Dexamethasone acetate, dexamethasone and cyclophosphamide, dexamethasone and rituximab
Clinical Study IdentifierNCT01868269
SponsorInstitut Curie
Last Modified on24 January 2021

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