Auto Transplant for High Risk or Relapsed Solid or CNS Tumors
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- STATUS
- Recruiting
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- End date
- Mar 4, 2024
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- participants needed
- 20
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- sponsor
- Masonic Cancer Center, University of Minnesota
Summary
This is a standard of care treatment guideline for high risk or relapsed solid tumors or CNS tumors consisting of a busulfan, melphalan, thiotepa conditioning (for solid tumors) or carboplatin and thiotepa conditioning (for CNS tumors) followed by an autologous peripheral blood stem cell transplant. For solid tumors, if appropriate, disease specific radiation therapy at day +60. For CNS tumors, the conditioning regimen and autologous peripheral blood stem cell transplant will be given for 3 cycles.
Details
| Condition | Ewing's Family Tumors, Renal Tumors, Hepatoblastoma, Rhabdomyosarcoma, Soft Tissue Sarcoma, Primary Malignant Brain Neoplasms, Retinoblastoma, Medulloblastoma, Supra-tentorial Primative Neuro-Ectodermal Tumor (PNET), Atypical Teratoid/Rhabdoid Tumor (AT/RT), CNS Tumors, Germ Cell Tumors |
|---|---|
| Treatment | G-CSF, etoposide, leukapheresis, busulfan, ifosfamide, melphalan, carboplatin, Paclitaxel, MESNA, Radiation, thiotepa, Autologous stem cell infusion, URSODIOL, Anti-seizure prophylaxis |
| Clinical Study Identifier | NCT01505569 |
| Sponsor | Masonic Cancer Center, University of Minnesota |
| Last Modified on | 4 May 2022 |
Eligibility
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