Auto Transplant for High Risk or Relapsed Solid or CNS Tumors

  • STATUS
    Recruiting
  • End date
    Mar 4, 2024
  • participants needed
    20
  • sponsor
    Masonic Cancer Center, University of Minnesota
Updated on 4 May 2022
platelet count
paclitaxel
cancer
stem cell transplantation
lymphoma
bone marrow transplant
busulfan
filgrastim
ejection fraction
metastatic disease
biologic agent
melphalan
heart failure
tumor markers
carcinoma
karnofsky performance status
stem cell infusion
MRI
bone marrow procedure
thiotepa
shortening fraction
etoposide
biological factors
initial diagnosis
residual tumor
human chorionic gonadotropin
metastasis
progressive disease
neutrophil count
carboplatin
tumor cells
blood transfusion
primary tumor
g-csf
complete resection
seizure
cns disease
cancer chemotherapy
recurrent disease
mesna
alpha fetoprotein
solid tumour
solid tumor
solid neoplasm
sarcoma
levetiracetam
ifosfamide
nervous
cns tumor
medulloblastoma
testicular
coma
cns neoplasm
germ cell tumor
atypical teratoid/rhabdoid tumor
nephroblastoma
primary cns lymphoma
mycn
pnet
ursodiol
desmoplastic
central nervous system tumor
peripheral neuroepithelioma
primitive neuroectodermal tumor
soft tissue sarcoma
hepatoblastoma
seminoma
mg++
rhabdoid tumor
ifosfamide etoposide
cns lymphoma
renal neoplasm
primary malignant brain neoplasms
wilms' tumor
failure pulmonary
epithelioid sarcoma

Summary

This is a standard of care treatment guideline for high risk or relapsed solid tumors or CNS tumors consisting of a busulfan, melphalan, thiotepa conditioning (for solid tumors) or carboplatin and thiotepa conditioning (for CNS tumors) followed by an autologous peripheral blood stem cell transplant. For solid tumors, if appropriate, disease specific radiation therapy at day +60. For CNS tumors, the conditioning regimen and autologous peripheral blood stem cell transplant will be given for 3 cycles.

Details
Condition Ewing's Family Tumors, Renal Tumors, Hepatoblastoma, Rhabdomyosarcoma, Soft Tissue Sarcoma, Primary Malignant Brain Neoplasms, Retinoblastoma, Medulloblastoma, Supra-tentorial Primative Neuro-Ectodermal Tumor (PNET), Atypical Teratoid/Rhabdoid Tumor (AT/RT), CNS Tumors, Germ Cell Tumors
Treatment G-CSF, etoposide, leukapheresis, busulfan, ifosfamide, melphalan, carboplatin, Paclitaxel, MESNA, Radiation, thiotepa, Autologous stem cell infusion, URSODIOL, Anti-seizure prophylaxis
Clinical Study IdentifierNCT01505569
SponsorMasonic Cancer Center, University of Minnesota
Last Modified on4 May 2022

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