Perioperative Immunonutrition Phagocytic and Bactericidal Activity of Blood Platelets in Gastric Cancer Patients

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    Medical University of Bialystok
Updated on 23 January 2021


Perioperative immunonutrition in gastric cancer patients can reduce perioperative morbidity and may improve quality of their life. Patients with gastric cancer will be divided into four groups depending on the type of artificial nutrition. Group I (enteral feeding) and II (enteral feeding and parenteral nutrition with glutamine) will be administered nutritional therapy during the postoperative period, group III (oral arginine) and IV (parenteral immunonutrition) patients will be treated nutritionally both prior to and after the surgery. The lymphocytes and their subpopulations, interleukin IL-1B,-6,-23, and the phagocytic, and bactericidal activity of blood platelets will be determined before and after nutritional therapy.


Surgical treatment of gastric cancer is associated with a high risk of perioperative complications. Morbidity of cancer patients increases in concert with the clinical stage of the malignancy. It is postulated that a reduction in perioperative morbidity and improved quality of life of patients with advanced gastric cancer can be achieved by proper preparation to surgery, among others. One of such methods is the implementation of immunostimulating nutritional therapy during the perioperative period.The stage of cancer will be graded according to TNM classification. The patients will be randomly assigned to four clinical groups based on the type of nutritional therapy implemented.

Condition Gastropathy, Stomach Discomfort, Gastric Cancer, Gastric Cancer, Stomach Cancer, Stomach Discomfort, Gastric Carcinoma, Stomach Cancer, gastric cancers
Treatment glutamine, Early postoperative enteral nutrition, based on standard elementary diet (Peptisorb), oral diet enriched with arginine (Cubitan), Perioperative parenteral immunonutrition (Dipeptiven, Omegaven)
Clinical Study IdentifierNCT01704664
SponsorMedical University of Bialystok
Last Modified on23 January 2021


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Inclusion Criteria

gastric cancer

Exclusion Criteria

for group III constituted gastric cancer associated with severe gastrointestinal obstruction
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