Pharmaco(Epi)Genetic Study of Obsessive-Compulsive Disorder

  • End date
    Dec 15, 2023
  • participants needed
  • sponsor
    Severance Hospital
Updated on 15 May 2022
psychiatric disorder
serotonin reuptake inhibitors


The purpose of this study is to determine whether pharmaco(epi)genetic study predict selective serotonin reuptake inhibitor (SSRI) responsiveness in advance before the appearance of the drug effect until 4 months(16 weeks), 6 months, and 1 year after administration of SSRIs.


The purpose of this study is to determine the effects of (epi)genetic variants on the response to SSRIs in obsessive-compulsive disorder (OCD) subject.

The investigators will recruit drug-naive or drug-free(> 3 months) OCD subjects (n=200). The participants will get SSRIs for their OCD symptoms. The type and dose of SSRIs will not be restricted and will depend on the individual participant's state. However, the investigators will be recommended to follow usual clinical guideline (the Korean treatment algorithm for OCD, 2004). At baseline, 4 month, 6 months, and 1 year after treatment, the participants will be evaluated by Yale-Brown Obsessive-Compulsive Scale(YBOCS), Montgomery Asberg Depression Rating Scale(MADRS), Dimensional Obsessive-Compulsive Scale(DOCS), Toronto alexithymia scale (TAS), interpersonal reactivity index (IRI), Barratt impulsiveness scale (BIS), and the Measure of Constructs Underlying Perfectionism(M-CUP), Beck Depression Inventory(BDI), Beck Anxiety Inventory(BAI), Intolerance of Uncertainty (IOU), Metacognition, Disgust scale, Early Trauma Inventory (ETI). And a part of participants will be taken resting state functional MRI.

And all the participants will donate 5 ml of whole blood and DNA will be extracted.

Using various (epi)genetic analyses methods such as genotyping, exome sequencing, and so on we will analyze the association of various (epi)genetic variants and the anti-obsessive-compulsive responses.

Condition Obsessive-Compulsive Disorder
Treatment SSRIs
Clinical Study IdentifierNCT02431845
SponsorSeverance Hospital
Last Modified on15 May 2022


Yes No Not Sure

Inclusion Criteria

age 19~ 70
OCD by Diagnostic and Statistical Manual for Mental disorders, 4th edition (DSM-IV)
drug naive or drug free for more than 3 months

Exclusion Criteria

any neurological disorder
comorbid psychotic disorders
alcohol or other substance dependence within past 6 months
any evidences for brain diseases
Clear my responses

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