The Effect of Intensive Multifactorial Therapy on Endothelial Function in Newly Diagnosed Type 2 Diabetes

  • participants needed
  • sponsor
    Xiang Guang-da
Updated on 8 November 2020
type 2 diabetes mellitus
blood lipids


The endothelial dysfunction is the early event in atherosclerosis. The investigator previous study showed that impaired endothelial function exist in newly diagnosed type 2 diabetes. The investigators hypothesize that intensive multifactorial therapy including intensive blood control and intensive hypertension control as well as intensive blood lipids control of 1 year can improve vascular endothelial function. Moreover, the improvement of endothelial function maintains after 5 years or 10 years of intensive multifactorial therapy, called "Metabolic Memorial Effect of improvement of endothelial function".


  • We select 1000 patients with newly diagnosed type 2 diabetes. They are divided into two groups, respectively (Intensive multifactorial therapy and conventional multifactorial therapy groups). After those therapy for one year, a 10 years of follow up study will be performed. During this period, we take them together intensive education, and take conventional multifactorial therapy for both of two groups.
    • At the beginning (0 year),the end of intensive multifactorial therapy (1 year), 5 years and 10 years, we will measure the endothelium-dependent arterial dilation, endothelium related cytokines such as ET-1, vWF,as well as blood glucose, HbA1c for all of individuals.
    • We will compare the endothelial function,endothelium related cytokines such as ET-1, vWF,as well as blood glucose, HbA1c between intensive therapy group and conventional therapy group at different time points.

Condition Endothelial Dysfunction
Treatment Intensive multifactorial group, conventional multifactorial therapy group
Clinical Study IdentifierNCT01101503
SponsorXiang Guang-da
Last Modified on8 November 2020


Yes No Not Sure

Inclusion Criteria

Is your age between 40 yrs and 70 yrs?
Gender: Male or Female
Do you have Endothelial Dysfunction?
Newly diagnosed type 2 diabetes
Age: 40 >= age <=70 year old

Exclusion Criteria

Type 1 diabetes
Mitochondrial diabetes
Patients with clinical detectable angiopathy
Body Mass Index (BMI) > 30 Kg/m2
Age < 40, or > 70 years old
Malignant neoplasms, renal or liver diseases
Known diabetes
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