The Effect of Intensive Multifactorial Therapy on Endothelial Function in Newly Diagnosed Type 2 Diabetes
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- STATUS
- Recruiting
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- participants needed
- 1000
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- sponsor
- Xiang Guang-da
Summary
The endothelial dysfunction is the early event in atherosclerosis. The investigator previous study showed that impaired endothelial function exist in newly diagnosed type 2 diabetes. The investigators hypothesize that intensive multifactorial therapy including intensive blood control and intensive hypertension control as well as intensive blood lipids control of 1 year can improve vascular endothelial function. Moreover, the improvement of endothelial function maintains after 5 years or 10 years of intensive multifactorial therapy, called "Metabolic Memorial Effect of improvement of endothelial function".
Description
- We select 1000 patients with newly diagnosed type 2 diabetes. They are divided into two
groups, respectively (Intensive multifactorial therapy and conventional multifactorial
therapy groups). After those therapy for one year, a 10 years of follow up study will be
performed. During this period, we take them together intensive education, and take
conventional multifactorial therapy for both of two groups.
- At the beginning (0 year),the end of intensive multifactorial therapy (1 year), 5 years and 10 years, we will measure the endothelium-dependent arterial dilation, endothelium related cytokines such as ET-1, vWF,as well as blood glucose, HbA1c for all of individuals.
- We will compare the endothelial function,endothelium related cytokines such as ET-1, vWF,as well as blood glucose, HbA1c between intensive therapy group and conventional therapy group at different time points.
Details
| Condition | Endothelial Dysfunction |
|---|---|
| Treatment | Intensive multifactorial group, conventional multifactorial therapy group |
| Clinical Study Identifier | NCT01101503 |
| Sponsor | Xiang Guang-da |
| Last Modified on | 8 November 2020 |
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