A Study of Genetic Based Chemotherapy Dosing for Breast Cancer Patients

  • participants needed
  • sponsor
    AHS Cancer Control Alberta
Updated on 8 November 2020
ejection fraction
breast cancer
progesterone receptor
estrogen receptor
invasive breast cancer


Epirubicin is a common chemotherapy medication used in the treatment of breast cancer. However, chemotherapy dosing is calculated based on people's height and weight, which may not be the most accurate way. The purpose of this study is to see if epirubicin dosing based on people's genetic profiles is better than the usual methods.

Condition Breast Cancer
Treatment Epirubicin
Clinical Study IdentifierNCT01740271
SponsorAHS Cancer Control Alberta
Last Modified on8 November 2020


Yes No Not Sure

Inclusion Criteria

Female patients with histologically confirmed non-metastatic invasive breast cancer who are scheduled to receive at least three cycles of FEC100 in the adjuvant or neoadjuvant setting
Documented pathological evaluation of the breast cancer for hormone receptor (estrogen receptor [ER], progesterone receptor [PR] and HER-2 status
Eastern Cooperative Oncology (ECOG) performance status of 2
A Left Ventricular Ejection Fraction (LVEF) 50%

Exclusion Criteria

Uncontrolled congestive heart failure (CHF) or angina, history of myocardial infarction within 2 months before study enrollment, or cardiac functional capacity Class III or IV as defined by the New York Heart Association Classification
Psychiatric disorder(s) that would interfere with consent, study participation, or follow up
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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