Genetic Analysis of Keloids

  • STATUS
    Recruiting
  • End date
    Dec 27, 2025
  • participants needed
    4000
  • sponsor
    UConn Health
Updated on 27 January 2021
scarring

Summary

Keloids have a strong genetic component. The goal of this study is to identify genes and regulatory elements on chromosomes that are the cause for keloids or contribute to keloid scarring.

Description

Keloids are scars that keep growing beyond the border of the original wound. They typically persist for several years, expand for an extensive period of time and are sometimes called benign tumors. Keloids often have a lumpy surface and are often tender, itchy or inflamed around the growing border.

Keloids in most keloid patients do not run in the family. In the inheritable form of keloids it is possible that there is one major gene mutation that puts family members at risk for developing keloids. There may be other variations in the DNA (DNA makes up the chromosomes) that determine whether keloids become large and aggressive or stay small and without many symptoms.

For this study we will:

  • Send out study participation kits and consent by phone
  • Collect a saliva sample from eligible individuals
  • Obtain information regarding the keloids
  • Document keloids with photos
  • If keloid patients undergo keloid surgery we ask to obtain some scar tissue that would otherwise be discarded
  • Isolate DNA from the saliva sample
  • Perform genetic analyses of the DNA with the most up-to-date methods available to identify genetic variations
  • Study in the laboratory why the genetic variations cause keloids

Details
Condition Keloid, Collagen disease, Scar, Collagen Vascular Diseases, Scar Tissue
Clinical Study IdentifierNCT01619553
SponsorUConn Health
Last Modified on27 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

keloids
unaffected individuals only if part of a participating keloid family

Exclusion Criteria

no keloids
unaffected individuals only as part of a participating keloid family
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Step 1 Connect with a study center
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  • You can expect the study team to contact you via email or phone in the next few days.
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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