Last updated on July 2019

International Guillain-Barr Syndrome Outcome Study


Brief description of study

International GBS Outcome Study (IGOS) is a study conducted by the members of the Inflammatory Neuropathy Consortium (INC) and Peripheral Nerve Society (PNS) on disease course and outcome in Guillain-Barr syndrome (GBS).

The IGOS aims to identify clinical and biological determinants and predictors of disease course and outcome in individual patients with Guillain-Barr syndrome, as early as possible after onset of disease.

Detailed Study Description

GBS is a post-infectious immune-mediated polyradiculoneuropathy with a highly diverse clinical course and outcome despite partially effective forms of treatment(immunoglobulins and plasma exchange). Outcome in patients with GBS has not improved in the last two decades. At present about 10 to 20% of patients remain severely disabled and about 5% die. One explanation for this stagnation is the highly variable clinical course of GBS and the lack of knowledge about the factors that determine the clinical course in individual patients with GBS. GBS may consist of distinct pathogenic subgroups, in which disease onset and progression is influenced by different types of preceding infections, anti-neural antibodies and genetic polymorphisms. Optimal treatment of individual patients may depend on the pathogenesis and clinical severity. Patients with severe forms of GBS may possibly need more intensive treatment to recover. Patients with a milder course that fully recover after standard therapy could suffer from possibly more side effects of more aggressive forms of treatment. This could only be possible if there are prognostic models that accurately predict the clinical course in individual patients. Ideally such models should be based on clinical and biological predictors that are strongly associated with disease course and known as early as possible in the acute phase of illness, when treatment with immunomodulatory therapy is most effective. Prognostic models could help to guide selective trials in specific GBS subtypes. Because of this it will be possible to treat GBS with more effective and more individual therapy.

This study aims to identify clinical and biological determinants and predictors of disease course and outcome in individual patients with Guillain-Barr syndrome, as early as possible after onset of disease. This information will be used to understand the diversity in clinical presentation and response to treatment of GBS. This information will also be used to develop new prognostic models to predict the clinical course and outcome accurately in individual patients with GBS.

To address these research questions it is required to conduct a prospective study with standardized collection of clinical data and biomaterials from a large group of well-defined GBS patients during a long follow-up period. Such an extensive study in a relatively rare disease as GBS can be addressed only by intensive international collaboration.

Clinical Study Identifier: NCT01582763

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Hospital Britanico

Buenos Aires, Argentina
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St. George's Hospital

London, United Kingdom
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University of Utah School of Medicine

Salt Lake City, UT United States
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Spectrum Health System

Grand Rapids, MI United States
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Elkerliek hospital

Helmond, Netherlands
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Minneapolis, MN United States
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Oxford, United Kingdom
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Buenos Aires, Argentina
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SSVZ

Schiedam, Netherlands
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Hospital Militar

Buenos Aires, Argentina
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Northwestern University

Chicago, IL United States
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Hospital de Clinicas

Buenos Aires, Argentina
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Glasgow, United Kingdom
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Rotterdam, Netherlands
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Birmingham, United Kingdom
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Bradford, United Kingdom
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Hinchingbrooke, United Kingdom
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Newcastle, United Kingdom
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Edinburgh, United Kingdom
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Albuquerque, NM United States
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Leiden, Netherlands
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MCH Westeinde

Den Haag, Netherlands
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Robert Wood Johnson Medical School

New Brunswick, NJ United States
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Lahey clinic Boston

Boston, MA United States
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Charing Cross Hospital

London, United Kingdom
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Buenos Aires, Argentina
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Buenos Aires, Argentina
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Sheffield, United Kingdom
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New York, NY United States
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Nijmegen, Netherlands
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Gelre ziekenhuis

Apeldoorn, Netherlands
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Addenbrooke's Hospital

Cambridge, United Kingdom
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University of Tennessee

Memphis, TN United States
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Hospital Austral

Buenos Aires, Argentina
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Rode Kruis Ziekenhuis

Beverwijk, Netherlands
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James Cook University Hospital

Middlesborough, United Kingdom
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AMC Amsterdam

Amsterdam, Netherlands
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University of Malaya

Kuala Lumpur, Malaysia
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Pinderfields Hospital

Wakefield, United Kingdom
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UT Southwestern

Dallas, TX United States
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The Walton Centre

Liverpool, United Kingdom
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Iowa City, IA United States
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Johns Hopkins

Baltimore, MD United States
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Mt. Sinai School of Med

New York, NY United States
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Columbia University

New York, NY United States
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ICDDR,B

Dhaka, Bangladesh
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Erasmus Medical Center

Rotterdam, Netherlands
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Hospital de Santiago

Santiago De Compostela, Spain
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Hinching Brooke Hospital

Huntingdon, United Kingdom
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