Last updated on April 2018

ABCB1/P-glycoprotein Expression as Biologic Stratification Factor for Patients With Non Metastatic Osteosarcoma


Brief description of study

The main objective of the study is to assess the survival in patient with non metastatic osteosarcoma of the extremities treated with different chemotherapy protocols, according to the expression of ABCB1/P-glycoprotein

Detailed Study Description

The Primary objective is:

  • Overall survival in patient with non metastatic osteosarcoma of the extremities treated with different chemotherapy approach (5 drugs vs 3 drugs), according to the expression of ABCB1/P-glycoprotein

The Secondary objectives are:

  • to assess the survival in patient who over express ABCB1/P-glycoprotein, with chemotherapy protocol based on all the 5 available active drugs (Methotrexate, cisplatinum, doxorubicine, ifosfamide and mifamurtide)
  • to assess the survival in patient who do not over express ABCB1/P-glycoprotein

Clinical Study Identifier: NCT01459484

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Massimo Aglietta, MD

I.R.C.C. - Unit of Medical Oncology
Candiolo, Italy
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Alessandro Comandone, MD

Presidio Sanitario Gradenigo
Torino, Italy
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Stefano Ferrari, MD

Istituto Ortopedico Rizzoli
Bologna, Italy
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Angela Tamburini, MD

A.O. Universitaria Meyer
Firenze, Italy
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Carla Manzitti, MD

Istituto Giannina Gaslini
Genova, Italy
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Roberto Luksch, MD

FONDAZIONE IRCCS Istituto Nazionale dei Tumori
Milano, Italy
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Gaetano Apice, MD

Istituto Nazionale Tumori "Fondazione G. Pascale"
Napoli, Italy
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Gianni Bisogno, MD

Azienda Ospedaliera di Padova
Padova, Italy
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Virginia Ferraresi, MD

Istituti Fisioterapici Ospitalieri di Roma
Roma, Italy
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Raffaele Cozza, MD

Ospedale Pediatrico Bambin Gesu'
Roma, Italy
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Franca Fagioli, MD

Ospedale Infantile Regina Margherita - Unit of Paediatric Oncoematology
Torino, Italy
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Recruitment Status: Open


Brief Description Eligibility Contact Research Team


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