Safety and Efficacy of Diverse Mesenchymal Stem Cells Transplantation for Liver Failure

  • STATUS
    Recruiting
  • participants needed
    210
  • sponsor
    Third Affiliated Hospital, Sun Yat-Sen University
Updated on 8 November 2020
liver transplant
hepatitis b surface antigen
meld score
clinical syndrome

Summary

HBV-related liver failure (HBV-LF), a dramatic clinical syndrome, is characterized with massive necrosis of liver cells. Liver transplantation might be the most effective therapy for HBV-LF. However, there are a lot of problems such as lack of donors, surgical complications, transplant rejection, and high cost, which could limit the application of liver transplantation. It is demonstrated that mesenchymal stem cells could directionally differentiate into hepatocytes and cholangiocytes in injured liver, as well as reduce inflammation of the liver by immune regulation. In this study, we assess the safety and efficacy of human bone marrow and umbilical cord mesenchymal stem cells transplantation for patients with HBV-LF.

Details
Condition Hepatic Failure
Treatment Conventional treatment, Conventional plus BM-MSC treatment, Conventional plus UC-MSC treatment
Clinical Study IdentifierNCT01844063
SponsorThird Affiliated Hospital, Sun Yat-Sen University
Last Modified on8 November 2020

Eligibility

Yes No Not Sure

Inclusion Criteria

Aged 18-65 years
Liver failure
Negative pregnancy test (female patients in fertile age)
Written consent
HBsAg positive
TB171 mol/L or ascend 17.1 mol/L/per day
INR1.5 or 20%PTA40%
MELD score30

Exclusion Criteria

Hepatocellular carcinoma or other malignancies
Severe problems in other vital organs(e.g.the heart,renal or lungs)
Pregnant or lactating women
Severe bacteria infection
Anticipated with difficulty of follow-up observation
Liver failure caused by other reasons, such as autoimmune diseases, alcohol, drug and so on
Other candidates who are judged to be not applicable to this study by doctors
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