The Hepatitis Delta International Network

  • End date
    Nov 8, 2023
  • participants needed
  • sponsor
    HepNet Study House, German Liverfoundation
Updated on 8 March 2021


Hepatitis delta is a major health problem, not only because of the severity of the disease, but also due to the lack of effective antiviral treatment. To improve the current therapeutic options, a better understanding of the pathophysiology is essential. Reliable research in this direction is only possible with large patient study groups. However, given the geographic distribution of hepatitis delta, larger patient cohorts would only be possible through multicenter collaboration.


The hepatitis international network cohort is a multicenter, observational study that will build up a research registry of HDV patients all over the world.

The aims of this project are:

i. Collect clinical information from hepatitis delta patients from multiple centers distributed worldwide in order to build up a large database that will enable and facilitate further research on chronic hepatitis delta.

ii. To better inform patients about their viral infection, present status and evolution of liver disease throughout time. To give them the tools needed to inform other peers and medical professionals about the significance and consequences of a chronic hepatitis delta infection.

iii. To allow the participating physicians to track course of the disease, therapies, signs and symptoms of the hepatitis delta patients included by their center.

Condition Hepatitis D
Clinical Study IdentifierNCT02375906
SponsorHepNet Study House, German Liverfoundation
Last Modified on8 March 2021


Yes No Not Sure

Inclusion Criteria

Positive HBs antigen and antiHDV for longer than 6 months

Exclusion Criteria

Absence of any cause of relevant liver disease other than HDV (i.e
hemochromatosis, autoimmune hepatitis, alcoholic or toxic liver disease, etc.)
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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