Autologous Cultured Corneal Epithelium (CECA) for the Treatment of Limbal Stem Cell Deficiency

  • End date
    Dec 9, 2027
  • participants needed
  • sponsor
    CHU de Quebec-Universite Laval
Updated on 12 September 2021


The study " Autologous cultured corneal epithelium (CECA) for the treatment of corneal lesions associated with limbal stem cell deficiency" is the first clinical trial of this product manufactured at the LOEX laboratory. The culture of corneal epithelium strives to produce a reconstructed tissue with the therapeutical aim of treatment of limbal stem cell deficiency. The study is a phase I/phase II study with the goal to evaluate safety and efficacy of the CECA graft for the treatment of human patients suffering from limbal stem cell deficiency.

The trial is open to all genders. The inclusion of 5 minors is planned.

Condition Limbal Stem Cell Deficiency
Treatment surgical transplantation of CECA
Clinical Study IdentifierNCT01756365
SponsorCHU de Quebec-Universite Laval
Last Modified on12 September 2021


Yes No Not Sure

Inclusion Criteria

All genders
LSCD in one or two eyes. A minimum of 1-3 mm2 of undamaged limbus is required for a biopsy to be taken without foreseeable adverse consequences for the donor eye

Exclusion Criteria

Donor eye not sufficiently healthy to allow for the harvesting of a 1-3 mm2 limbal biopsy without foreseeable consequences for the donor eye
Incapacitated person
known allergy to aprotinine (Trasylol (R))
Hypersensibility to bovine proteins
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