Last updated on February 2018

Leflunomide Versus Azathioprine for Maintenance Therapy of Lupus Nephritis

Brief description of study

Leflunomide versus Azathioprine for Maintenance Therapy of Lupus Nephritis

Detailed Study Description

Proliferative glomerulonephritis is a common and severe manifestation of systemic lupus erythematosus (SLE) that usually requires intensive therapy with high doses of glucocorticosteroids and cytotoxic drugs, such as intravenous (IV) cyclophosphamide (CYC). The objective of this Trial is to compare leflunomide (LEF) and azathioprine (AZA), in terms of efficacy and toxicity, as remission-maintaining treatment of proliferative lupus glomerulonephritis, after a remission-inducing therapy with a short-course IV CYC regimen. The hypothesis of this trial is that LEF is non-inferior to AZA.

Clinical Study Identifier: NCT01172002

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Bao Chun De

RenJi Hospital
ShangHai, China
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Recruitment Status: Open

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