Kisspeptin in the Evaluation of Delayed Puberty
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- STATUS
- Recruiting
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- End date
- Nov 24, 2023
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- participants needed
- 60
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- sponsor
- Massachusetts General Hospital
Summary
Some children with delayed puberty will eventually enter puberty on their own. However, some children with delayed puberty have a permanent condition and require medical treatment to undergo puberty. Right now, there is no reliable diagnostic tool to tell whether a child's delayed puberty will be self-resolving or permanent. The hormone kisspeptin has the potential to prospectively diagnose adolescents with self-resolving or permanent delayed puberty.
Description
The investigators are seeking boys (ages 13.5-17 years) and girls (ages 12-17) years with a diagnosis of delayed puberty. Study participation involves 2 outpatient visits and two hospital admissions (one 11-hour, overnight admission and one 6-hour day admission) when subjects will receive two investigational drugs, the naturally occurring hormones kisspeptin and gonadotropin-releasing hormone (GnRH). Subjects will then be followed every 6 months until they reach 18 years of age to determine if their pubertal delay was self-resolved or permanent. Individuals interested in learning more may call 617-726-8484.
Details
| Condition | Delayed Puberty, Kallmann Syndrome, Hypogonadotropic Hypogonadism, GnRH Deficiency |
|---|---|
| Treatment | kisspeptin 112-121, GnRH |
| Clinical Study Identifier | NCT01438034 |
| Sponsor | Massachusetts General Hospital |
| Last Modified on | 24 July 2022 |
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