Last updated on January 2019

Rituximab Bendamustine Hydrochloride and Bortezomib Followed by Rituximab and Lenalidomide in Treating Older Patients With Previously Untreated Mantle Cell Lymphoma


Brief description of study

RATIONALE: Monoclonal antibodies, such as rituximab, can block cancer growth in different ways. Some find cancer cells and help kill them or carry cancer-killing substances to them. Others interfere with the ability of cancer cells to grow and spread. Drugs used in chemotherapy, such as bendamustine hydrochloride, also work in different ways to kill cancer cells or stop them from dividing. Bortezomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Lenalidomide may stop the growth of mantle cell lymphoma by blocking blood flow to the cancer. It is not yet known whether giving rituximab together with bendamustine and bortezomib is more effective than rituximab and bendamustine, followed by rituximab alone or with lenalidomide in treating mantle cell lymphoma.

PURPOSE: This randomized phase II trial studies rituximab, bortezomib, bendamustine, and lenalidomide in treating previously untreated older patients with mantle cell lymphoma.

Detailed Study Description

OBJECTIVES

Primary

  • To determine whether the addition of bortezomib (RBV) to an induction regimen of rituximab-bendamustine hydrochloride (RB) improves progression-free survival (PFS) compared to RB alone in patients 60 years of age with previously untreated mantle cell lymphoma.
  • To determine whether the addition of lenalidomide to a consolidation regimen of rituximab following an induction regimen of RB or RBV improves PFS compared to consolidation rituximab alone in this patient population.

Secondary

  • To determine whether the addition of bortezomib to induction therapy improves the positron emission tomography (PET)-documented complete response (CR) rate compared to RB alone.
  • To determine the objective response rate (ORR) for RB and RBV.
  • Among patients who do not have PET-documented CR at the end of induction, to determine whether the addition of lenalidomide to consolidation therapy improves CR and ORR compared with rituximab alone.
  • To determine overall survival (OS) in the treatment arms.
  • To determine safety, with attention to the addition of bortezomib in the induction regimen and lenalidomide-rituximab (LR) as consolidation therapy.
  • To collect paraffin-embedded tissue for creation of tissue microarray.
  • To collect and bank serum and blood mononuclear cells for future studies.
  • To collect formalin-fixed paraffin-embedded (FFPE) tissue to analyze potential prognostic factors (Ki-67 proliferation index by immunohistochemistry and correlation with proposed 5-gene set of proliferation markers analyzed by RNA PCR; SOX 11 expression by immunohistochemistry; and Micro-RNA levels by microarray).
  • Using patient-reported outcomes data, to determine the extent and severity of neuropathy associated with the addition of bortezomib to induction treatment.
  • Using patient-reported outcomes data, to determine the extent and severity of fatigue associated with the addition of lenalidomide to consolidation treatment.
  • To evaluate the effects of the addition of bortezomib and lenalidomide on patient-reported health-related quality of life.
  • To evaluate the effects of bortezomib-related neuropathy on patient-reported health-related quality of life.
  • To evaluate the response of lymphoma-specific symptoms to treatment.
  • Using longitudinal patient-reported outcomes data, to describe the trajectory of lymphoma symptoms, neuropathy, fatigue, and overall health-related quality of life prior to, during, and following treatment among older adults with MCL.

Tertiary

  • To assess the proportion of patients up and down staging when fludeoxyglucose F 18- (FDG) PET/CT is added to standard Ann Arbor staging.
  • To assess the ability of pre-treatment FDG-PET/CT (SUVmax) to predict response rate and PFS.
  • Among patients with interim (post-cycle 3) FDG-PET/CT imaging, to assess the correlation of interim FDG-PET/CT imaging with response rate and PFS both during induction and consolidation therapy.
  • To assess standard FDG-PET/CT metrics including SUVmax, tumor metabolic burden, total tumor burden, and association with pathology features (blastoid variant vs other, and Ki67) in the setting of MCL.
  • To assess differences in overall and CR rates when using Deauville vs International Harmonization Project FDG-PET/CT interpretation criteria.
  • To determine whether there is a correlation between FDG-PET/CT response and residual disease assessment by molecular and/or flow cytometric techniques.
  • To determine whether the number of malignant cells in circulation predict the number of cells in marrow.
  • To determine whether the number of malignant cells in circulation/in marrow at the end of induction correlate with CR and 2-year PFS.
  • To determine whether there is a higher rate of minimal residual disease (MRD) negativity among patients randomized to RBV as compared with RB, and among patients treated with LR maintenance compared with rituximab.
  • To compare the two methods of MRD detection - molecular techniques and flow cytometry - as prognostic markers for outcome.

OUTLINE: This is a multicenter study. Patients are stratified according to mantle cell lymphoma International Prognostic Index risk score (low vs intermediate vs high). Patients are randomized to 1 of 4 treatment arms.

  • Arm A: Patients receive induction therapy comprising rituximab IV on day 1 and bendamustine hydrochloride IV over 60 minutes on days 1-2. Treatment repeats every 4 weeks for 6 courses in the absence of disease progression or unacceptable toxicity.
    • Arm E: Patients receive consolidation therapy comprising rituximab IV on day 1. Courses repeat every 8 weeks for 2 years in the absence of disease progression or unacceptable toxicity.
  • Arm B: Patients receive induction therapy comprising bortezomib IV or subcutaneously (SC) on days 1, 4, 8, and 11 and rituximab and bendamustine hydrochloride as patients in arm A. Treatment repeats every 4 weeks for 6 courses in the absence of disease progression or unacceptable toxicity.
    • Arm F: Patients receive consolidation therapy comprising rituximab IV on day 1. Courses repeat every 8 weeks for 2 years in the absence of disease progression or unacceptable toxicity.
  • Arm C: Patients receive induction therapy comprising rituximab and bendamustine hydrochloride as patients in arm A. Treatment repeats every 4 weeks for 6 courses in the absence of disease progression or unacceptable toxicity.
    • Arm G: Patients receive consolidation therapy comprising lenalidomide orally (PO) daily on days 1-21 every 4 weeks and rituximab IV every 8 weeks for 2 years in the absence of disease progression or unacceptable toxicity.
  • Arm D: Patients receive bortezomib, rituximab, and bendamustine hydrochloride as patients in arm B. Treatment repeats every 4 weeks for 6 courses in the absence of disease progression or unacceptable toxicity.
    • Arm H: Patients receive consolidation therapy comprising lenalidomide PO daily on days 1-21 every 4 weeks and rituximab IV every 8 weeks for 2 years in the absence of disease progression or unacceptable toxicity.

Patients may undergo blood and bone marrow sample collection at baseline and during treatment for correlative studies.

Patients complete the Functional Assessment of Cancer Therapy - Lymphoma (FACT-Lym), the FACT/GOG-Neurotoxicity scale (FACT/GOG-Ntx), FACT-Fatigue, and FACT-General questionnaires at baseline and periodically during study and follow up.

After completion of study treatment, patients are followed up every 3 months for 2 years, every 6 months for 3 years, and then annually for 10 years.

Clinical Study Identifier: NCT01415752

Contact Investigators or Research Sites near you

Start Over

Alison K. Conlin

Alaska Breast Care and Surgery LLC
Anchorage, AK United States
  Connect »

Alison K. Conlin

Alaska Women's Cancer Care
Anchorage, AK United States
  Connect »

Alison K. Conlin

Anchorage Oncology Centre
Anchorage, AK United States
  Connect »

Alison K. Conlin

Katmai Oncology Group
Anchorage, AK United States
  Connect »

Alison K. Conlin

Providence Alaska Medical Center
Anchorage, AK United States
  Connect »

Tatjana Kolevska

Kaiser Permanente-Deer Valley Medical Center
Antioch, CA United States
  Connect »

Tatjana Kolevska

Kaiser Permanente, Fremont
Fremont, CA United States
  Connect »

Tatjana Kolevska

Kaiser Permanente
Fresno, CA United States
  Connect »

Los Angeles County-USC Medical Center
Los Angeles, CA United States
  Connect »

USC / Norris Comprehensive Cancer Center
Los Angeles, CA United States
  Connect »

Tatjana Kolevska

Kaiser Permanente-Modesto
Modesto, CA United States
  Connect »

Tatjana Kolevska

Kaiser Permanente-Oakland
Oakland, CA United States
  Connect »

Tatjana Kolevska

Kaiser Permanente-Redwood City
Redwood City, CA United States
  Connect »

Tatjana Kolevska

Kaiser Permanente-Richmond
Richmond, CA United States
  Connect »

Tatjana Kolevska

Kaiser Permanente-Roseville
Roseville, CA United States
  Connect »

Tatjana Kolevska

Kaiser Permanente-South Sacramento
Sacramento, CA United States
  Connect »

Tatjana Kolevska

Kaiser Permanente - Sacramento
Sacramento, CA United States
  Connect »

Tatjana Kolevska

Kaiser Permanente-San Francisco
San Francisco, CA United States
  Connect »

Tatjana Kolevska

Kaiser Permanente-Santa Teresa-San Jose
San Jose, CA United States
  Connect »

Tatjana Kolevska

Kaiser Permanente San Leandro
San Leandro, CA United States
  Connect »

Tatjana Kolevska

Kaiser Permanente-San Rafael
San Rafael, CA United States
  Connect »

Tatjana Kolevska

Kaiser Permanente Medical Center - Santa Clara
Santa Clara, CA United States
  Connect »

Tatjana Kolevska

Kaiser Permanente-Santa Rosa
Santa Rosa, CA United States
  Connect »

Tatjana Kolevska

Kaiser Permanente-South San Francisco
South San Francisco, CA United States
  Connect »

Stanford University Hospitals and Clinics
Stanford, CA United States
  Connect »

Tatjana Kolevska

Kaiser Permanente-Stockton
Stockton, CA United States
  Connect »

Tatjana Kolevska

Kaiser Permanente Medical Center-Vacaville
Vacaville, CA United States
  Connect »

Tatjana Kolevska

Kaiser Permanente-Vallejo
Vallejo, CA United States
  Connect »

Tatjana Kolevska

Kaiser Permanente-Walnut Creek
Walnut Creek, CA United States
  Connect »

Keren Sturtz

Rocky Mountain Cancer Centers-Aurora
Aurora, CO United States
  Connect »

Keren Sturtz

The Medical Center of Aurora
Aurora, CO United States
  Connect »

Keren Sturtz

Boulder Community Hospital
Boulder, CO United States
  Connect »

Keren Sturtz

Rocky Mountain Cancer Centers-Boulder
Boulder, CO United States
  Connect »

Keren Sturtz

Penrose-Saint Francis Healthcare
Colorado Springs, CO United States
  Connect »

Keren Sturtz

Rocky Mountain Cancer Centers-Penrose
Colorado Springs, CO United States
  Connect »

Alexander Menter

Kaiser Permanente-Franklin
Denver, CO United States
  Connect »

Keren Sturtz

Porter Adventist Hospital
Denver, CO United States
  Connect »

Keren Sturtz

Exempla Saint Joseph Hospital
Denver, CO United States
  Connect »

Keren Sturtz

Presbyterian - Saint Lukes Medical Center - Health One
Denver, CO United States
  Connect »

Keren Sturtz

Rocky Mountain Cancer Centers-Midtown
Denver, CO United States
  Connect »

Keren Sturtz

Rocky Mountain Cancer Centers-Rose
Denver, CO United States
  Connect »

Keren Sturtz

Rose Medical Center
Denver, CO United States
  Connect »

Keren Sturtz

Colorado Cancer Research Program CCOP
Denver, CO United States
  Connect »

Keren Sturtz

Colorado Blood Cancer Institute
Denver, CO United States
  Connect »

Keren Sturtz

Mercy Medical Center
Durango, CO United States
  Connect »

Keren Sturtz

Southwest Oncology PC
Durango, CO United States
  Connect »

Keren Sturtz

Comprehensive Cancer Care and Research Institute of Colorado LLC
Englewood, CO United States
  Connect »

Keren Sturtz

Swedish Medical Center
Englewood, CO United States
  Connect »

Regina J. Brown

Poudre Valley Hospital
Fort Collins, CO United States
  Connect »

Front Range Cancer Specialists
Fort Collins, CO United States
  Connect »

Keren Sturtz

Mountain Blue Cancer Care Center
Golden, CO United States
  Connect »

Keren Sturtz

North Colorado Medical Center
Greeley, CO United States
  Connect »

Keren Sturtz

Rocky Mountain Cancer Centers-Greenwood Village
Greenwood Village, CO United States
  Connect »

Alexander Menter

Kaiser Permanente-Rock Creek
Lafayette, CO United States
  Connect »

Keren Sturtz

Rocky Mountain Cancer Centers-Lakewood
Lakewood, CO United States
  Connect »

Keren Sturtz

Saint Anthony Hospital
Lakewood, CO United States
  Connect »

Keren Sturtz

Rocky Mountain Cancer Centers-Littleton
Littleton, CO United States
  Connect »

Keren Sturtz

Littleton Adventist Hospital
Littleton, CO United States
  Connect »

Alexander Menter

Kaiser Permanente-Lone Tree
Lone Tree, CO United States
  Connect »

Keren Sturtz

Rocky Mountain Cancer Centers-Sky Ridge
Lone Tree, CO United States
  Connect »

Keren Sturtz

Sky Ridge Medical Center
Lone Tree, CO United States
  Connect »

Keren Sturtz

Longmont United Hospital
Longmont, CO United States
  Connect »

Keren Sturtz

Rocky Mountain Cancer Centers-Longmont
Longmont, CO United States
  Connect »

Keren Sturtz

McKee Medical Center
Loveland, CO United States
  Connect »

Keren Sturtz

Parker Adventist Hospital
Parker, CO United States
  Connect »

Keren Sturtz

Rocky Mountain Cancer Centers-Parker
Parker, CO United States
  Connect »

Keren Sturtz

Saint Mary Corwin Medical Center
Pueblo, CO United States
  Connect »

Keren Sturtz

Rocky Mountain Cancer Centers - Pueblo
Pueblo, CO United States
  Connect »

Keren Sturtz

Rocky Mountain Cancer Centers-Thornton
Thornton, CO United States
  Connect »

Keren Sturtz

Exempla Lutheran Medical Center
Wheat Ridge, CO United States
  Connect »

Christopher M. Reynolds

Saint Francis Hospital and Medical Center
Hartford, CT United States
  Connect »

Gregory A. Masters

Beebe Medical Center
Lewes, DE United States
  Connect »

Gregory A. Masters

Christiana Gynecologic Oncology LLC
Newark, DE United States
  Connect »

Gregory A. Masters

Delaware Clinical and Laboratory Physicians PA
Newark, DE United States
  Connect »

Gregory A. Masters

Helen F Graham Cancer Center
Newark, DE United States
  Connect »

Gregory A. Masters

Medical Oncology Hematology Consultants PA
Newark, DE United States
  Connect »

Gregory A. Masters

Regional Hematology and Oncology PA
Newark, DE United States
  Connect »

Gregory A. Masters

Christiana Care Health System-Christiana Hospital
Newark, DE United States
  Connect »

Gregory A. Masters

Beebe Health Campus
Rehoboth Beach, DE United States
  Connect »

Gregory A. Masters

Nanticoke Memorial Hospital
Seaford, DE United States
  Connect »

Gregory A. Masters

Christiana Care Health System-Wilmington Hospital
Wilmington, DE United States
  Connect »

Bruce D. Cheson

Lombardi Comprehensive Cancer Center at Georgetown University
Washington, WA United States
  Connect »

Baptist Cancer Institute
Jacksonville, FL United States
  Connect »

Jose E. Sarriera

UF Cancer Center at Orlando Health
Orlando, FL United States
  Connect »

Jeffrey L. Berenberg

Oncare Hawaii Inc-Pali Momi
Aiea, HI United States
  Connect »

Jeffrey L. Berenberg

Pali Momi Medical Center
Aiea, HI United States
  Connect »

Jeffrey L. Berenberg

Oncare Hawaii Inc-POB II
Honolulu, HI United States
  Connect »

Jeffrey L. Berenberg

Queen's Medical Center
Honolulu, HI United States
  Connect »

Jeffrey L. Berenberg

Straub Clinic and Hospital
Honolulu, HI United States
  Connect »

Jeffrey L. Berenberg

University of Hawaii Cancer Center
Honolulu, HI United States
  Connect »

Jeffrey L. Berenberg

OnCare Hawaii-Liliha
Honolulu, HI United States
  Connect »

Jeffrey L. Berenberg

Oncare Hawaii Inc-Kuakini
Honolulu, HI United States
  Connect »

Tatjana Kolevska

Kaiser Permanente Moanalua Medical Center
Honolulu, HI United States
  Connect »

Jeffrey L. Berenberg

Kapiolani Medical Center for Women and Children
Honolulu, HI United States
  Connect »

Castle Medical Center
Kailua, HI United States
  Connect »

Jeffrey L. Berenberg

Wilcox Memorial Hospital and Kauai Medical Clinic
Lihue, HI United States
  Connect »

Christopher M. Reynolds

Saint Alphonsus Cancer Care Center-Boise
Boise, ID United States
  Connect »

Idaho Urologic Institute-Meridian
Meridian, ID United States
  Connect »

Benjamin T. Marchello

Kootenai Cancer Center
Post Falls, ID United States
  Connect »

Benjamin T. Marchello

Kootenai Cancer
Sandpoint, ID United States
  Connect »

James L. Wade

Memorial Hospital of Carbondale
Carbondale, IL United States
  Connect »

James L. Wade

Centralia Oncology Clinic
Centralia, IL United States
  Connect »

Mount Sinai Hospital Medical Center
Chicago, IL United States
  Connect »

Hematology and Oncology Associates
Chicago, IL United States
  Connect »

Jane N. Winter

Northwestern University
Chicago, IL United States
  Connect »

Luis D. Sumoza Benitez

John H Stroger Jr Hospital of Cook County
Chicago, IL United States
  Connect »

Maria T. Grosse-Perdekamp

Carle on Vermilion
Danville, IL United States
  Connect »

James L. Wade

Cancer Care Center of Decatur
Decatur, IL United States
  Connect »

James L. Wade

Decatur Memorial Hospital
Decatur, IL United States
  Connect »

Maria T. Grosse-Perdekamp

Carle Physician Group-Effingham
Effingham, IL United States
  Connect »

James L. Wade

Crossroads Cancer Center
Effingham, IL United States
  Connect »

Jane N. Winter

Hematology Oncology Associates of Illinois-Highland Park
Highland Park, IL United States
  Connect »

Jane N. Winter

Presence Saint Mary's Hospital
Kankakee, IL United States
  Connect »

Jane N. Winter

North Shore Hematology Oncology
Libertyville, IL United States
  Connect »

Maria T. Grosse-Perdekamp

Carle Physician Group-Mattoon/Charleston
Mattoon, IL United States
  Connect »

Jay W. Carlson

Good Samaritan Regional Health Center
Mount Vernon, IL United States
  Connect »

Jane N. Winter

Illinois Cancer Specialists-Niles
Niles, IL United States
  Connect »

Swedish American Hospital
Rockford, IL United States
  Connect »

Harvey E. Einhorn

SwedishAmerican Regional Cancer Center/ACT
Rockford, IL United States
  Connect »

Jane N. Winter

Hematology Oncology Associates of Illinois - Skokie
Skokie, IL United States
  Connect »

James L. Wade

Memorial Medical Center
Springfield, IL United States
  Connect »

Maria T. Grosse-Perdekamp

Carle Cancer Center
Urbana, IL United States
  Connect »

Maria T. Grosse-Perdekamp

The Carle Foundation Hospital
Urbana, IL United States
  Connect »

Saint Francis Hospital and Health Centers
Beech Grove, IN United States
  Connect »

Franciscan Saint Francis Health-Indianapolis
Indianapolis, IN United States
  Connect »

IU Health Arnett Cancer Care
Lafayette, IN United States
  Connect »

Maria T. Grosse-Perdekamp

Franciscan Saint Anthony Health-Michigan City
Michigan City, IN United States
  Connect »

Maria T. Grosse-Perdekamp

Woodland Cancer Care Center
Michigan City, IN United States
  Connect »

Howard M. Gross

Reid Hospital and Health Care Services
Richmond, IN United States
  Connect »

Joseph J. Merchant

Mary Greeley Medical Center
Ames, IA United States
  Connect »

Joseph J. Merchant

McFarland Clinic PC-William R Bliss Cancer Center
Ames, IA United States
  Connect »

Hematology Oncology Associates-Quad Cities
Bettendorf, IA United States
  Connect »

Joseph J. Merchant

McFarland Clinic PC-Boone
Boone, IA United States
  Connect »

Cedar Rapids Oncology Association
Cedar Rapids, IA United States
  Connect »

Deborah W. Wilbur

Mercy Hospital
Cedar Rapids, IA United States
  Connect »

Deborah W. Wilbur

Oncology Associates at Mercy Medical Center
Cedar Rapids, IA United States
  Connect »

Joseph J. Merchant

McFarland Clinic PC-Trinity Cancer Center
Fort Dodge, IA United States
  Connect »

Joseph J. Merchant

McFarland Clinic PC-Jefferson
Jefferson, IA United States
  Connect »

Joseph J. Merchant

McFarland Clinic PC-Marshalltown
Marshalltown, IA United States
  Connect »

Donald B. Wender

Siouxland Hematology Oncology Associates
Sioux City, IA United States
  Connect »

Mercy Medical Center-Sioux City
Sioux City, IA United States
  Connect »

Saint Luke's Regional Medical Center
Sioux City, IA United States
  Connect »

Shaker R. Dakhil

Lawrence Memorial Hospital
Lawrence, KS United States
  Connect »

Rakesh Gaur

Menorah Medical Center
Overland Park, KS United States
  Connect »

Rakesh Gaur

Saint Luke's South Hospital
Overland Park, KS United States
  Connect »

Kansas City CCOP
Prairie Village, KS United States
  Connect »

Shaker R. Dakhil

Wesley Medical Center
Wichita, KS United States
  Connect »

Howard M. Gross

Oncology Hematology Care Inc-Crestview
Crestview Hills, KY United States
  Connect »

Robert V. Emmons

Ochsner Health Center-Summa
Baton Rouge, LA United States
  Connect »

Robert V. Emmons

Ochsner Baptist Medical Center
New Orleans, LA United States
  Connect »

Robert V. Emmons

Ochsner Medical Center Jefferson
New Orleans, LA United States
  Connect »

Harold Alfond Center for Cancer Care
Augusta, ME United States
  Connect »

Thomas H. Openshaw

Eastern Maine Medical Center
Bangor, ME United States
  Connect »

Penobscot Bay Medical Center
Rockport, ME United States
  Connect »

Suman B. Rao

Franklin Square Hospital Center
Baltimore, MD United States
  Connect »

Union Hospital of Cecil County
Elkton MD, MD United States
  Connect »

Frederick D. Min

Holy Cross Hospital
Silver Spring, MD United States
  Connect »

Andrew M. Evens

Tufts Medical Center
Boston, MA United States
  Connect »

Alan G. Rosmarin

Simonds-Sinon Regional Cancer Center
Fitchburg, MA United States
  Connect »

Syed S. Ali

Baystate Medical Center
Springfield, MA United States
  Connect »

Alan G. Rosmarin

University of Massachusetts Medical School
Worcester, MA United States
  Connect »

Christopher M. Reynolds

Saint Joseph Mercy Hospital
Ann Arbor, MI United States
  Connect »

Michigan Cancer Research Consortium Community Clinical Oncology Program
Ann Arbor, MI United States
  Connect »

Gilbert D. Padula

Bronson Battle Creek
Battle Creek, MI United States
  Connect »

Spectrum Health Big Rapids Hospital
Big Rapids, MI United States
  Connect »

Christopher M. Reynolds

Oakwood Hospital and Medical Center
Dearborn, MI United States
  Connect »

Radhakrishnan Ramchandren

Wayne State University/Karmanos Cancer Institute
Detroit, MI United States
  Connect »

Christopher M. Reynolds

Saint John Hospital and Medical Center
Detroit, MI United States
  Connect »

Brian L. Burnette

Green Bay Oncology - Escanaba
Escanaba, MI United States
  Connect »

Radhakrishnan Ramchandren

Weisberg Cancer Treatment Center
Farmington Hills, MI United States
  Connect »

Christopher M. Reynolds

Hurley Medical Center
Flint, MI United States
  Connect »

Christopher M. Reynolds

Genesys Hurley Cancer Institute
Flint, MI United States
  Connect »

Genesys Regional Medical Center-West Flint Campus
Flint, MI United States
  Connect »

Genesys Regional Medical Center
Grand Blanc, MI United States
  Connect »

Grand Rapids Clinical Oncology Program
Grand Rapids, MI United States
  Connect »

Gilbert D. Padula

Mercy Health Saint Mary's
Grand Rapids, MI United States
  Connect »

Gilbert D. Padula

Spectrum Health at Butterworth Campus
Grand Rapids, MI United States
  Connect »

Brian L. Burnette

Green Bay Oncology - Iron Mountain
Iron Mountain, MI United States
  Connect »

Christopher M. Reynolds

Allegiance Health
Jackson, MI United States
  Connect »

Raymond S. Lord

Borgess Medical Center
Kalamazoo, MI United States
  Connect »

Raymond S. Lord

Bronson Methodist Hospital
Kalamazoo, MI United States
  Connect »

Raymond S. Lord

West Michigan Cancer Center
Kalamazoo, MI United States
  Connect »

Christopher M. Reynolds

Sparrow Hospital
Lansing, MI United States
  Connect »

Christopher M. Reynolds

Saint Mary Mercy Hospital
Livonia, MI United States
  Connect »

Gilbert D. Padula

Mercy Health Mercy Campus
Muskegon, MI United States
  Connect »

Gilbert D. Padula

Lakeland Community Hospital
Niles, MI United States
  Connect »

Christopher M. Reynolds

Saint Joseph Mercy Oakland
Pontiac, MI United States
  Connect »

Christopher M. Reynolds

Saint Joseph Mercy Port Huron
Port Huron, MI United States
  Connect »

Gilbert D. Padula

Spectrum Health Reed City Hospital
Reed City, MI United States
  Connect »

Christopher M. Reynolds

Saint Mary's of Michigan
Saginaw, MI United States
  Connect »

Gilbert D. Padula

Marie Yeager Cancer Center
Saint Joseph, MI United States
  Connect »

Gilbert D. Padula

Lakeland Hospital
St. Joseph, MI United States
  Connect »

Gilbert D. Padula

Munson Medical Center
Traverse City, MI United States
  Connect »

Christopher M. Reynolds

Saint John Macomb-Oakland Hospital
Warren, MI United States
  Connect »

Sanford Clinic North-Bemidgi
Bemidji, MN United States
  Connect »

Joseph W. Leach

Fairview Ridges Hospital
Burnsville, MN United States
  Connect »

Joseph W. Leach

Mercy Hospital
Coon Rapids, MN United States
  Connect »

Bret E. Friday

Essentia Health Cancer Center
Duluth, MN United States
  Connect »

Bret E. Friday

Essentia Health Saint Mary's Medical Center
Duluth, MN United States
  Connect »

Bret E. Friday

Miller-Dwan Hospital
Duluth, MN United States
  Connect »

Joseph W. Leach

Fairview-Southdale Hospital
Edina, MN United States
  Connect »

Joseph W. Leach

Unity Hospital
Fridley, MN United States
  Connect »

Joseph W. Leach

Hutchinson Area Health Care
Hutchinson, MN United States
  Connect »

Joseph W. Leach

Minnesota Oncology Hematology PA-Maplewood
Maplewood, MN United States
  Connect »

Joseph W. Leach

Saint John's Hospital - Healtheast
Maplewood, MN United States
  Connect »

Joseph W. Leach

Abbott-Northwestern Hospital
Minneapolis, MN United States
  Connect »

Joseph W. Leach

Hennepin County Medical Center
Minneapolis, MN United States
  Connect »

Joseph W. Leach

Health Partners Inc
Minneapolis, MN United States
  Connect »

New Ulm Medical Center
New Ulm, MN United States
  Connect »

Joseph W. Leach

North Memorial Medical Health Center
Robbinsdale, MN United States
  Connect »

David J. Inwards

Mayo Clinic
Rochester, MN United States
  Connect »

Metro-Minnesota CCOP
Saint Louis Park, MN United States
  Connect »

Joseph W. Leach

Park Nicollet Clinic - Saint Louis Park
Saint Louis Park, MN United States
  Connect »

Joseph W. Leach

Regions Hospital
Saint Paul, MN United States
  Connect »

Joseph W. Leach

United Hospital
Saint Paul, MN United States
  Connect »

Joseph W. Leach

Saint Francis Regional Medical Center
Shakopee, MN United States
  Connect »

Lakeview Hospital
Stillwater, MN United States
  Connect »

Joseph W. Leach

Ridgeview Medical Center
Waconia, MN United States
  Connect »

Joseph W. Leach

Rice Memorial Hospital
Willmar, MN United States
  Connect »

Joseph W. Leach

Minnesota Oncology and Hematology PA-Woodbury
Woodbury, MN United States
  Connect »

James L. Wade

Parkland Health Center-Bonne Terre
Bonne Terre, MO United States
  Connect »

James L. Wade

Saint Francis Medical Center
Cape Girardeau, MO United States
  Connect »

James L. Wade

Southeast Cancer Center
Cape Girardeau, MO United States
  Connect »

Saint Luke's Hospital
Chesterfield, MO United States
  Connect »

Donald C. Doll

University of Missouri - Ellis Fischel
Columbia, MO United States
  Connect »

Rakesh Gaur

Centerpoint Medical Center LLC
Independence, MO United States
  Connect »

James L. Wade

Capital Region Medical Center-Goldschmidt Cancer Center
Jefferson City, MO United States
  Connect »

Freeman Health System
Joplin, MO United States
  Connect »

Rakesh Gaur

Saint Luke's Hospital of Kansas City
Kansas City, MO United States
  Connect »

Rakesh Gaur

Heartland Hematology and Oncology Associates Incorporated
Kansas City, MO United States
  Connect »

Rakesh Gaur

Research Medical Center
Kansas City, MO United States
  Connect »

Rakesh Gaur

Saint Luke's East - Lee's Summit
Lee's Summit, MO United States
  Connect »

Rakesh Gaur

Liberty Radiation Oncology Center
Liberty, MO United States
  Connect »

Phelps County Regional Medical Center
Rolla, MO United States
  Connect »

Saint John's Clinic-Rolla-Cancer and Hematology
Rolla, MO United States
  Connect »

Rakesh Gaur

Heartland Regional Medical Center
Saint Joseph, MO United States
  Connect »

Jay W. Carlson

Saint Louis Cancer and Breast Institute-South City
Saint Louis, MO United States
  Connect »

Nancy L. Bartlett

Washington University School of Medicine
Saint Louis, MO United States
  Connect »

James L. Wade

Missouri Baptist Medical Center
Saint Louis, MO United States
  Connect »

Comprehensive Cancer Care PC
Saint Louis, MO United States
  Connect »

Jay W. Carlson

Saint John's Mercy Medical Center
Saint Louis, MO United States
  Connect »

Saint Louis-Cape Girardeau CCOP
Saint Louis, MO United States
  Connect »

Jay W. Carlson

Mercy Hospital Springfield
Springfield, MO United States
  Connect »

Ozark Health Ventures LLC-Cancer Research for The Ozarks Springfield
Springfield, MO United States
  Connect »

Jay W. Carlson

CoxHealth South Hospital
Springfield, MO United States
  Connect »

James L. Wade

Missouri Baptist Sullivan Hospital
Sullivan, MO United States
  Connect »

James L. Wade

Missouri Baptist Outpatient Center-Sunset Hills
Sunset Hills, MO United States
  Connect »

Benjamin T. Marchello

Montana Cancer Consortium CCOP
Billings, MT United States
  Connect »

Benjamin T. Marchello

Saint Vincent Healthcare
Billings, MT United States
  Connect »

Frontier Cancer Center and Blood Institute-Billings
Billings, MT United States
  Connect »

Benjamin T. Marchello

Billings Clinic Cancer Center
Billings, MT United States
  Connect »

Bozeman Deaconess Cancer Center
Bozeman, MT United States
  Connect »

Benjamin T. Marchello

Bozeman Deaconess Hospital
Bozeman, MT United States
  Connect »

Benjamin T. Marchello

Saint James Community Hospital and Cancer Treatment Center
Butte, MT United States
  Connect »

Benjamin T. Marchello

Benefis Healthcare- Sletten Cancer Institute
Great Falls, MT United States
  Connect »

Great Falls Clinic
Great Falls, MT United States
  Connect »

Northern Montana Hospital
Havre, MT United States
  Connect »

Benjamin T. Marchello

Saint Peter's Community Hospital
Helena, MT United States
  Connect »

Glacier Oncology PLLC
Kalispell, MT United States
  Connect »

Kalispell Medical Oncology
Kalispell, MT United States
  Connect »

Benjamin T. Marchello

Kalispell Regional Medical Center
Kalispell, MT United States
  Connect »

Benjamin T. Marchello

Community Medical Hospital
Missoula, MT United States
  Connect »

Montana Cancer Specialists
Missoula, MT United States
  Connect »

Benjamin T. Marchello

Saint Patrick Hospital - Community Hospital
Missoula, MT United States
  Connect »

Frederick Lansigan

Dartmouth Hitchcock Medical Center
Lebanon, NH United States
  Connect »

Frederick Lansigan

Norris Cotton Cancer Center Nashua
Nashua, NH United States
  Connect »

Cooper Hospital University Medical Center
Camden, NJ United States
  Connect »

Victor T. Chang

Veterans Adminstration New Jersey Health Care System
East Orange, NJ United States
  Connect »

Hematology Oncology Associates of Central New York-Auburn
Auburn, NY United States
  Connect »

Ramakrishna Battini

Albert Einstein College of Medicine
Bronx, NY United States
  Connect »

Ramakrishna Battini

Montefiore Medical Center - Moses Campus
Bronx, NY United States
  Connect »

Hematology Oncology Associates of Central New York-East Syracuse
East Syracuse, NY United States
  Connect »

John P. Stoutenburg

Glens Falls Hospital
Glens Falls, NY United States
  Connect »

Hematology Oncology Associates of Central New York-Liverpool
Liverpool, NY United States
  Connect »

Orange Regional Medical Center
Middletown, NY United States
  Connect »

Samir S. Parekh

Mount Sinai Medical Center
New York, NY United States
  Connect »

Peter Martin

Weill Medical College of Cornell University
New York, NY United States
  Connect »

Jonathan W. Friedberg

University of Rochester
Rochester, NY United States
  Connect »

Hematology Oncology Associates of Central New York-Rome
Rome, NY United States
  Connect »

Hematology Oncology Associates of Central New York-Onondaga Hill
Syracuse, NY United States
  Connect »

James N. Atkins

Southeastern Medical Oncology Center-Clinton
Clinton, NC United States
  Connect »

James N. Atkins

Southeastern Medical Oncology Center-Goldsboro
Goldsboro, NC United States
  Connect »

James N. Atkins

Wayne Memorial Hospital
Goldsboro, NC United States
  Connect »

James E. Radford

Hendersonville Hematology and Oncology at Pardee
Hendersonville, NC United States
  Connect »

James E. Radford

Margaret R Pardee Memorial Hospital
Hendersonville, NC United States
  Connect »

Park Ridge Hospital Breast Health Center
Hendersonville, NC United States
  Connect »

James N. Atkins

Southeastern Medical Oncology Center-Jacksonville
Jacksonville, NC United States
  Connect »

Peter R. Watson

Kinston Medical Specialists PA
Kinston, NC United States
  Connect »

Ruby A. Grimm

Iredell Memorial Hospital
Statesville, NC United States
  Connect »

James N. Atkins

Southeastern Medical Oncology Center-Wilson
Wilson, NC United States
  Connect »

Zanetta S. Lamar

Wake Forest University Health Sciences
Winston-Salem, NC United States
  Connect »

Roger Maris Cancer Center
Fargo, ND United States
  Connect »

Sanford Clinic North-Fargo
Fargo, ND United States
  Connect »

Sanford Medical Center-Fargo
Fargo, ND United States
  Connect »

Jennifer E. Payne

Summa Akron City Hospital/Cooper Cancer Center
Akron, OH United States
  Connect »

Jennifer E. Payne

Summa Barberton Hospital
Barberton, OH United States
  Connect »

Anjali S. Advani

Cleveland Clinic Cancer Center Beachwood
Beachwood, OH United States
  Connect »

Howard M. Gross

Oncology Hematology Care Inc-Mercy West
Cincinnati, OH United States
  Connect »

Howard M. Gross

Oncology and Hematology Care Inc-Taft
Cincinnati, OH United States
  Connect »

Howard M. Gross

Oncology Hematology Care Inc - Anderson
Cincinnati, OH United States
  Connect »

Howard M. Gross

Oncology Hematology Care Inc - Kenwood
Cincinnati, OH United States
  Connect »

Howard M. Gross

Oncology Hematology Care Inc-Blue Ash
Cincinnati, OH United States
  Connect »

Stephen C. Medlin

University of Cincinnati
Cincinnati, OH United States
  Connect »

Paolo F. Caimi

Case Western Reserve University
Cleveland, OH United States
  Connect »

Bruce J. Averbook

MetroHealth Medical Center
Cleveland, OH United States
  Connect »

Anjali S. Advani

Cleveland Clinic Cancer Center/Fairview Hospital
Cleveland, OH United States
  Connect »

Anjali S. Advani

Cleveland Clinic Foundation
Cleveland, OH United States
  Connect »

Kristie A. Blum

Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical Center
Columbus, OH United States
  Connect »

Grandview Hospital
Dayton, OH United States
  Connect »

Howard M. Gross

Good Samaritan Hospital - Dayton
Dayton, OH United States
  Connect »

Howard M. Gross

Miami Valley Hospital
Dayton, OH United States
  Connect »

Howard M. Gross

Samaritan North Health Center
Dayton, OH United States
  Connect »

Dayton CCOP
Dayton, OH United States
  Connect »

Paolo F. Caimi

Mercy Cancer Center-Elyria
Elyria, OH United States
  Connect »

Howard M. Gross

Oncology Hematology Care Inc-Healthplex
Fairfield, OH United States
  Connect »

Howard M. Gross

Blanchard Valley Hospital
Findlay, OH United States
  Connect »

Howard M. Gross

Atrium Medical Center-Middletown Regional Hospital
Franklin, OH United States
  Connect »

Howard M. Gross

Wayne Hospital
Greenville, OH United States
  Connect »

Anjali S. Advani

Cleveland Clinic Cancer Center Independence
Independence, OH United States
  Connect »

Howard M. Gross

Kettering Medical Center
Kettering, OH United States
  Connect »

Anjali S. Advani

Cleveland Clinic Cancer Center Mansfield
Mansfield, OH United States
  Connect »

Anjali S. Advani

Hillcrest Hospital Cancer Center
Mayfield Heights, OH United States
  Connect »

Paolo F. Caimi

Lake University Ireland Cancer Center
Mentor, OH United States
  Connect »

University Hospitals Parma Medical Center
Parma, OH United States
  Connect »

Anjali S. Advani

North Coast Cancer Care
Sandusky, OH United States
  Connect »

Anjali S. Advani

Cleveland Clinic Cancer Center Strongsville
Strongsville, OH United States
  Connect »

Howard M. Gross

Upper Valley Medical Center
Troy, OH United States
  Connect »

Anjali S. Advani

South Pointe Hospital
Warrensville Heights, OH United States
  Connect »

Stephen C. Medlin

University Pointe
West Chester, OH United States
  Connect »

Paolo F. Caimi

UH-Seidman Cancer Center at Saint John Medical Center
Westlake, OH United States
  Connect »

Anjali S. Advani

Cleveland Clinic Wooster Specialty Center
Wooster, OH United States
  Connect »

Greene Memorial Hospital
Xenia, OH United States
  Connect »

Mohamad Cherry

University of Oklahoma Health Sciences Center
Oklahoma City, OK United States
  Connect »

Mohamad Cherry

Tulsa Cancer Institute
Tulsa, OK United States
  Connect »

Alison K. Conlin

Clackamas Radiation Oncology Center
Clackamas, OR United States
  Connect »

Providence Milwaukie Hospital
Milwaukie, OR United States
  Connect »

Alison K. Conlin

Providence Newberg Medical Center
Newberg, OR United States
  Connect »

Alison K. Conlin

Providence Willamette Falls Medical Center
Oregon City, OR United States
  Connect »

Alison K. Conlin

Providence Portland Medical Center
Portland, OR United States
  Connect »

Western Oncology Research Consortium
Portland, OR United States
  Connect »

Alison K. Conlin

Providence Saint Vincent Medical Center
Portland, OR United States
  Connect »

Edward J. Gorak

Geisinger Medical Center
Danville, PA United States
  Connect »

Edward J. Gorak

Geisinger Medical Center-Cancer Center Hazleton
Hazleton, PA United States
  Connect »

Edward J. Gorak

Geisinger Medical Oncology at Evangelical Community Hospital
Lewisburg, PA United States
  Connect »

Edward J. Gorak

Lewistown Hospital
Lewistown, PA United States
  Connect »

Michael M. Millenson

Fox Chase Cancer Center
Philadelphia, PA United States
  Connect »

Wei Song

Pottstown Memorial Medical Center
Pottstown, PA United States
  Connect »

Edward J. Gorak

Geisinger Medical Oncology-Pottsville
Pottsville, PA United States
  Connect »

Edward J. Gorak

Geisinger Medical Group
State College, PA United States
  Connect »

John P. Ford

Mount Nittany Medical Center
State College, PA United States
  Connect »

Terrence P. Cescon

Reading Hospital
West Reading, PA United States
  Connect »

Edward J. Gorak

Geisinger Wyoming Valley
Wilkes-Barre, PA United States
  Connect »

AnMed Health Cancer Center
Anderson, SC United States
  Connect »

Saint Francis Hospital
Greenville, SC United States
  Connect »

Charles E. Bowers

Gibbs Cancer Center-Pelham
Greer, SC United States
  Connect »

Charles E. Bowers

Spartanburg Regional Medical Center
Spartanburg, SC United States
  Connect »

Upstate Carolina CCOP
Spartanburg, SC United States
  Connect »

Wellmont Bristol Regional Medical Center
Bristol, TN United States
  Connect »

Wellmont Medical Associates Oncology and Hematology-Bristol
Bristol, TN United States
  Connect »

Asheesh Shipstone

Wellmont Holston Valley Hospital and Medical Center
Kingsport, TN United States
  Connect »

Asheesh Shipstone

Wellmont Medical Associates Oncology and Hematology-Kingsport
Kingsport, TN United States
  Connect »

Vanderbilt-Ingram Cancer Center
Nashville, TN United States
  Connect »

Parkland Memorial Hospital
Dallas, TX United States
  Connect »

University of Texas Southwestern Medical Center
Dallas, TX United States
  Connect »

Michael E. Williams

University of Virginia
Charlottesville, VA United States
  Connect »

Sreedhar Katragadda

Memorial Hospital Of Martinsville
Martinsville, VA United States
  Connect »

Southwest VA Regional Cancer Center
Norton, VA United States
  Connect »

Clinical Trials Office - Massey ...

Massey Cancer Center at Virginia Commonwealth University
Richmond, VA United States
  Connect »

Brian G. Till

Kadlec Clinic Hematology and Oncology
Kennewick, WA United States
  Connect »

Brian G. Till

EvergreenHealth Medical Center
Kirkland, WA United States
  Connect »

Brian G. Till

Seattle Cancer Care Alliance at EvergreenHealth
Kirkland, WA United States
  Connect »

Alison K. Conlin

Saint John Medical Center
Longview, WA United States
  Connect »

Brian G. Till

Skagit Valley Hospital Regional Cancer Care Center
Mount Vernon, WA United States
  Connect »

Brian G. Till

Skagit Valley Hospital
Mount Vernon, WA United States
  Connect »

Brian G. Till

Olympic Medical Center
Port Angeles, WA United States
  Connect »

Brian G. Till

Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium
Seattle, WA United States
  Connect »

Brian G. Till

Seattle Cancer Care Alliance
Seattle, WA United States
  Connect »

Brian G. Till

University of Washington Medical Center
Seattle, WA United States
  Connect »

Brian G. Till

Olympic Medical Cancer Care Center
Sequim, WA United States
  Connect »

Brian G. Till

Cancer Care Northwest - Spokane South
Spokane, WA United States
  Connect »

Brian G. Till

Cancer Care Northwest-Valley
Spokane, WA United States
  Connect »

Brian G. Till

Cancer Care Northwest-North Spokane
Spokane, WA United States
  Connect »

Alison K. Conlin

PeaceHealth Southwest Medical Center
Vancouver, WA United States
  Connect »

Compass Oncology Vancouver
Vancouver, WA United States
  Connect »

Brian G. Till

Wenatchee Valley Hospital and Clinics
Wenatchee, WA United States
  Connect »

Abraham S. Kanate

West Virginia University Healthcare
Morgantown, WV United States
  Connect »

Hamied R. Rezazadeh

Langlade Hospital and Cancer Center
Antigo, WI United States
  Connect »

Marshfield Clinic Cancer Center at Sacred Heart
Eau Claire, WI United States
  Connect »

Sacred Heart Hospital
Eau Claire, WI United States
  Connect »

Michael W. Jones

Agnesian Cancer Center
Fond Du Lac, WI United States
  Connect »

Brian L. Burnette

Green Bay Oncology at Saint Vincent Hospital
Green Bay, WI United States
  Connect »

Brian L. Burnette

Saint Vincent Hospital
Green Bay, WI United States
  Connect »

Brian L. Burnette

Green Bay Oncology Limited at Saint Mary's Hospital
Green Bay, WI United States
  Connect »

Brian L. Burnette

Saint Mary's Hospital
Green Bay, WI United States
  Connect »

UW Cancer Center Johnson Creek
Johnson Creek, WI United States
  Connect »

Kurt Oettel

Gundersen Lutheran Medical Center
La Crosse, WI United States
  Connect »

University of Wisconsin Hospital and Clinics
Madison, WI United States
  Connect »

Brian L. Burnette

Holy Family Memorial Hospital
Manitowoc, WI United States
  Connect »

Brian L. Burnette

Bay Area Medical Center
Marinette, WI United States
  Connect »

Marshfield Clinic
Marshfield, WI United States
  Connect »

Saint Joseph's Hospital
Marshfield, WI United States
  Connect »

Timothy S. Fenske

Froedtert and the Medical College of Wisconsin
Milwaukee, WI United States
  Connect »

Marshfield Clinic-Minocqua Center
Minocqua, WI United States
  Connect »

Timothy R. Wassenaar

D N Greenwald Center
Mukwonago, WI United States
  Connect »

Joseph W. Leach

Cancer Center of Western Wisconsin
New Richmond, WI United States
  Connect »

Timothy R. Wassenaar

Oconomowoc Memorial Hospital-ProHealth Care Inc
Oconomowoc, WI United States
  Connect »

Brian L. Burnette

Green Bay Oncology - Oconto Falls
Oconto Falls, WI United States
  Connect »

Marshfield Clinic at James Beck Cancer Center
Rhinelander, WI United States
  Connect »

Saint Mary's Hospital
Rhinelander, WI United States
  Connect »

Marshfield Clinic-Rice Lake Center
Rice Lake, WI United States
  Connect »

Brian L. Burnette

Saint Nicholas Hospital
Sheboygan, WI United States
  Connect »

Marshfield Clinic Cancer Care at Saint Michael's Hospital
Stevens Point, WI United States
  Connect »

Saint Michael's Hospital
Stevens Point, WI United States
  Connect »

Brian L. Burnette

Green Bay Oncology - Sturgeon Bay
Sturgeon Bay, WI United States
  Connect »

Timothy R. Wassenaar

Waukesha Memorial Hospital - ProHealth Care
Waukesha, WI United States
  Connect »

Hamied R. Rezazadeh

Aspirus Regional Cancer Center
Wausau, WI United States
  Connect »

Marshfield Clinic-Wausau Center
Wausau, WI United States
  Connect »

Diagnostic and Treatment Center
Weston, WI United States
  Connect »

Marshfield Clinic - Weston Center
Weston, WI United States
  Connect »

Saint Clare's Hospital
Weston, WI United States
  Connect »

Marshfield Clinic - Wisconsin Rapids Center
Wisconsin Rapids, WI United States
  Connect »

Rocky Mountain Oncology
Casper, WY United States
  Connect »

Benjamin T. Marchello

Big Horn Basin Cancer Center
Cody, WY United States
  Connect »

Benjamin T. Marchello

Billings Clinic-Cody
Cody, WY United States
  Connect »

Benjamin T. Marchello

Welch Cancer Center
Sheridan, WY United States
  Connect »

Nizar N. Abdel-Samad

The Moncton Hospital
Moncton, NB Canada
  Connect »

Haji I. Chalchal

Allan Blair Cancer Centre
Regina, SK Canada
  Connect »

Recruitment Status: Open


Brief Description Eligibility Contact Research Team


Receive Emails About New Clinical Trials!

Sign up for our FREE service to receive email notifications when clinical trials are posted in the medical category of interest to you.