Investigation of Biomarkers in Susac Syndrome

  • STATUS
    Recruiting
  • End date
    Dec 2, 2021
  • participants needed
    30
  • sponsor
    Charite University, Berlin, Germany
Updated on 2 February 2021

Summary

Susac Syndrome is a rare disease and the establishment of the diagnosis is often difficult. The aim of this investigation is to identify relevant biomarkers and to elucidate the pathogenesis of Susac syndrome

Description

Susac Syndrome is a rare disease characterized by encephalopathy, branch retinal artery occlusion and sensorineural deafness. The pathogenesis is not yet clear, an autoimmune endotheliopathy is discussed. Because of the variable and often incomplete clinical presentation, the establishment of the diagnosis is often delayed or even completely missed.

The aim of this study is to identify biomarkers that facilitate the reliable and prompt establishment of the diagnosis. Patients with a definite diagnosis of Susac syndrome and healthy subjects as controls are investigated.

Furthermore, the correlation of serological markers with structural retinal and cerebral changes will contribute to clarification of the pathogenesis of Susac syndrome.

Details
Condition Susac's Syndrome, susac syndrome
Clinical Study IdentifierNCT01273792
SponsorCharite University, Berlin, Germany
Last Modified on2 February 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

adult male and female patients with definite Susac syndrome or matching healthy control subjects
ability to provide informed consent

Exclusion Criteria

pregnancy
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