Epidemiology and Pathophysiology of Parkinsonism in the Caribbeans

  • STATUS
    Recruiting
  • End date
    Aug 3, 2023
  • participants needed
    550
  • sponsor
    Centre Hospitalier Universitaire de Pointe-a-Pitre
Updated on 21 January 2021

Summary

The primary aim of this study is to estimate the frequency and to characterize clinically atypical parkinsonism in the French West Indies and Guyana.

Description

An atypical akineto-rigid parkinsonian syndrome, unresponsive to L-dopa has been evidenced in Guadeloupe. Abnormally frequent, this progressive supranuclear palsy (PSP)-like syndrome represents a new clinical entity. Unlike in classical PSP 70% of patients have myoclonus, 59% hallucinations, 78% REM sleep behavior disorders. Oculomotor pattern differs from classical PSP suggesting that cortical dysfunction predominates over brainstem impairments. Neuropathological examination in four patients has shown a widespread accumulation of the tau protein in the basal ganglia, the midbrain and cortical areas.

This syndrome has been associated to the regular consumption of food products derived from plants of the Annonaceae family, more specifically Annona Muricata (soursop), suggesting a toxic origin. We have already confirmed the neurotoxic potential of the lipophilic mitochondrial complex I inhibitor annonacin, the major acetogenin in Annona muricata. This class of compounds is specific to Annonaceae. Nanomolar concentrations of annonacin induce the death of dopaminergic neurons in culture, by impairment of energy production. Chronic systemic intoxication of rats with annonacin causes neuronal damage in the same brain regions that are damaged in patients with atypical parkinsonism. These results greatly suggest that the consumption of annonacea might contribute to the pathogenesis of the disease. The H1 subhaplotype in tau gene associated with PSP in Caucasians did not confer risk for PSP-like atypical parkinsonism in Guadeloupe.

Details
Condition Atypical Parkinsonism
Treatment Clinical and biological exam
Clinical Study IdentifierNCT03368300
SponsorCentre Hospitalier Universitaire de Pointe-a-Pitre
Last Modified on21 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Pour les patients
Patient ou tiers responsable ayant reu une information sur l'tude et ayant sign le consentement clair
Patient g de plus de 18 ans
Patient consultant en neurologie ou en griatrie pour symptomatologie parkinsonienne ou pour troubles cognitifs vocateurs d'une dmence corps de Lewy
Patient domicili aux Antilles-Guyane
Pour les tmoins
\. Conjoint ou accompagnant ayant reu une information sur l'tude et ayant
sign le consentement clair
\. Personne ge de plus de 18 ans
\. Personne ne prsentant pas de pathologie d'allure neurodgnrative
(Parkinson, dmence notamment)
\. Personne domicilie aux Antilles-Guyane

Exclusion Criteria

Pour les patients
Syndrome parkinsonien secondaire (post-traumatique, vasculaire, iatrogne, post encphalitique)
Patient non affili au rgime de scurit sociale
En cas de difficult de suivi le patient sera exclu de l'tude longitudinale
Pour les tmoins
Personnes prsentant des troubles cognitifs ou un syndrome parkinsonien diagnostiqu
Patient non affili au rgime de scurit sociale -
Clear my responses

How to participate?

Step 1 Connect with a site
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar
Name

Primary Contact

site
Name

0/250
Preferred Language
Other Language
Please verify that you are not a bot.

Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider

Loading...

Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 

 • 

Private

Reply by • Private
Loading...

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.
Loading...

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note