Long-term Beneficial Metabolic Effects of Adrenalectomy in Subclinical Cushing's Syndrome of Adrenal Incidentaloma

  • End date
    May 22, 2024
  • participants needed
  • sponsor
    Samsung Medical Center
Updated on 22 January 2021
conservative treatment
suppression test
adrenal incidentaloma



To determine the metabolic effects of the adrenalectomy in subclinical Cushing's syndrome of adrenal incidentaloma.


234 subclinical cushing syndrome and adrenal incidentaloma will be randomly assigned into two groups(e.g adrenalectomy group and conservative treatment group).

Condition Cushing's Syndrome, cushing
Treatment Surgery
Clinical Study IdentifierNCT01382420
SponsorSamsung Medical Center
Last Modified on22 January 2021


Yes No Not Sure

Inclusion Criteria

patients with both unilateral adrenal incidentaloma and hypercortisolism
definition of hypercortisolism
overnight dexamethasone suppression test, serum cortisol>1.8ug/dL
hr urine cortisol > upper reference limit

Exclusion Criteria

patients who took medication influencing cortisol secretion
patients with definite clinical feature of cushing syndrome
moon face
abdominal striae
skin or proximal muscle atrophy
metabolic syndrome, hyperthyroidism, hyperparathyroidism, chronic renal failure, rheumatic disease, hematologic disease
patients who took following medication
oral hypoglycemic agent
thyroid hormone
anti-hyperlipidemic drug
sex hormone
patients who taking steroid hormone or who took steroid hormone more than 2 weeks within 1 year
psychiatric disease
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