Long-term Beneficial Metabolic Effects of Adrenalectomy in Subclinical Cushing's Syndrome of Adrenal Incidentaloma

  • STATUS
    Recruiting
  • End date
    May 22, 2024
  • participants needed
    234
  • sponsor
    Samsung Medical Center
Updated on 22 January 2021
dexamethasone
adrenalectomy
hypercortisolism
conservative treatment
suppression test
adrenal incidentaloma

Summary

Objective

To determine the metabolic effects of the adrenalectomy in subclinical Cushing's syndrome of adrenal incidentaloma.

Methods

234 subclinical cushing syndrome and adrenal incidentaloma will be randomly assigned into two groups(e.g adrenalectomy group and conservative treatment group).

Details
Condition Cushing's Syndrome, cushing
Treatment Surgery
Clinical Study IdentifierNCT01382420
SponsorSamsung Medical Center
Last Modified on22 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

patients with both unilateral adrenal incidentaloma and hypercortisolism
definition of hypercortisolism
overnight dexamethasone suppression test, serum cortisol>1.8ug/dL
hr urine cortisol > upper reference limit

Exclusion Criteria

patients who took medication influencing cortisol secretion
patients with definite clinical feature of cushing syndrome
moon face
abdominal striae
skin or proximal muscle atrophy
metabolic syndrome, hyperthyroidism, hyperparathyroidism, chronic renal failure, rheumatic disease, hematologic disease
patients who took following medication
insulin
oral hypoglycemic agent
thyroid hormone
anti-hyperlipidemic drug
sex hormone
patients who taking steroid hormone or who took steroid hormone more than 2 weeks within 1 year
psychiatric disease
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