Usefulness of Serum Pepsinogen and Gastrin as the Predictive Biomarker of Atrophic Gastritis Intestinal Metaplasia and Gastric Cancer in Korea

  • End date
    Dec 22, 2023
  • participants needed
  • sponsor
    Yonsei University
Updated on 22 January 2021


It is well-known that atrophic gastritis is a major risk factor for gastric cancer, which leads to variations in the serum levels of gastrin, pepsinogen (PG) I, and PGII. We want to assess the effects of age, sex, and Helicobacter pylori status on pepsinogen (PG) level for atrophic gastritis and whether gastric atrophy based on the PG test would be improved after H. pylori eradication.

Condition Atrophic gastritis, gastric atrophy
Treatment pepsinogen and gastrin
Clinical Study IdentifierNCT02184910
SponsorYonsei University
Last Modified on22 January 2021


Yes No Not Sure

Inclusion Criteria

over 19 years
the patients who have gastrointestinal discomfort or get esophagogastroduodenoscopy (EGD) for health check up
the patients who got the procedure, endoscopic submucosal resection (ESD) for early gastric cancer

Exclusion Criteria

gastrectomy history
advanced gastric cancer (impossible to get the gastrectomy)
Helicobacter eradication history
the patients who have chronic disease
cancer patients except gastric cancer within 6 months
who cannot perform this study according to research's decision
who have bleeding tendency (ex. taking antiplatelet agent, low platelet count or abnormal coagulation time)
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