Optimization of MRI for Radiation Therapy

  • End date
    Mar 22, 2023
  • participants needed
  • sponsor
    University of Michigan Rogel Cancer Center
Updated on 22 March 2022


Currently, appropriate patients undergo MRI imaging with immobilization and sequences optimized for diagnostic radiology purposes. Using a mutual information algorithm, these images are then registered to a treatment planning CT obtained with custom immobilization to minimize intra-and inter-treatment motion and positional variation. This image registration process is time-consuming and introduces additional layers of geometric uncertainty into what should be a highly precise treatment planning process. However, it is necessary, since radiation dose calculations cannot be performed on MRI data due to the lack of crucial density information. The investigator envisions CT-less treatment planning, using only MRI, due to superior imaging characteristics, fully integrated into the radiation oncology clinic. This study will begin this process.

Condition Cancer Liver, Cancer Brain, Cancer Head &Neck, Cancer Pelvis
Treatment MRI Group
Clinical Study IdentifierNCT02045381
SponsorUniversity of Michigan Rogel Cancer Center
Last Modified on22 March 2022


Yes No Not Sure

Inclusion Criteria

Patients ≥18 years of age
A working diagnosis of malignancy in the liver, brain, H&N, or pelvis
A plan to treat with radiotherapy

Exclusion Criteria

Patients with contraindications to having a contrast enhanced MRI scan. These contraindications will be assessed at the time of enrollment using the guidelines set up and in clinical use by the Radiology Department
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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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