Radiation Therapy or Chemoradiation Interstitial Brachytherapy in Combination With Hyperthermia in Advanced Cervical Cancer

  • STATUS
    Recruiting
  • End date
    Dec 31, 2099
  • participants needed
    999
  • sponsor
    University of Erlangen-Nürnberg Medical School
Updated on 21 January 2021
cancer
carcinoma
chemoradiotherapy
brachytherapy
cervical carcinoma

Summary

The combination of radiation therapy or chemoradiation with Interstitial brachytherapy for advanced cervical cancer (pN+, FIGO-Stage II B - IV A is standard of therapy. The radio- and chemosensitive effect of an additional hyperthermia might improve the clinical outcome.

Details
Condition Cervical Cancer, Cervical Cancer, Disorders of cervix NOS, Uterine Cancer, Uterine Cancer, cervical carcinoma, cervical cancer, uterine, carcinoma of the cervix uteri, carcinoma of the cervix, cervix cancer, cancer of the cervix, carcinoma of cervix
Treatment cisplatin, brachytherapy, Radiation, hyperthermia
Clinical Study IdentifierNCT03249519
SponsorUniversity of Erlangen-Nürnberg Medical School
Last Modified on21 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Histological confirmed carcinoma of the Cervix
FIGO-Stage IIB-IVA; earlier stages when inoperable or according to patient's wish
clinical M0; except: involvement of para-aortic lymph nodes
Age 18 years
ECOG 2
Informed consent of the patient

Exclusion Criteria

Pre-existing uncontrolled cardiac disease, signs of cardiac failure, or rhythm disturbances requiring therapy
Cardiac Pacemaker
Myocardial infarction within the past 12 months
Congestive heart failure
Complete bundle branch block
New York Heart Association (NYHA) class III or IV heart disease
Disease that would preclude chemoradiation or deep regional hyperthermia
Metal implants (length > 2cm or dense clusters of marker clips in the pelvis)
Active or therapy-resistent bladder infections
Pre-existing or concommitant immunodeficiency Syndrome
Pregnant or lactating women
Patients not willing to use effective contraception during and up to 6 months after therapy
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