Radiation Therapy or Chemoradiation Interstitial Brachytherapy in Combination With Hyperthermia in Advanced Cervical Cancer

  • End date
    Dec 31, 2099
  • participants needed
  • sponsor
    University of Erlangen-Nürnberg Medical School
Updated on 21 January 2021
cervical carcinoma


The combination of radiation therapy or chemoradiation with Interstitial brachytherapy for advanced cervical cancer (pN+, FIGO-Stage II B - IV A is standard of therapy. The radio- and chemosensitive effect of an additional hyperthermia might improve the clinical outcome.

Condition Cervical Cancer, Cervical Cancer, Disorders of cervix NOS, Uterine Cancer, Uterine Cancer, cervical carcinoma, cervical cancer, uterine, carcinoma of the cervix uteri, carcinoma of the cervix, cervix cancer, cancer of the cervix, carcinoma of cervix
Treatment cisplatin, brachytherapy, Radiation, hyperthermia
Clinical Study IdentifierNCT03249519
SponsorUniversity of Erlangen-Nürnberg Medical School
Last Modified on21 January 2021


Yes No Not Sure

Inclusion Criteria

Histological confirmed carcinoma of the Cervix
FIGO-Stage IIB-IVA; earlier stages when inoperable or according to patient's wish
clinical M0; except: involvement of para-aortic lymph nodes
Age 18 years
Informed consent of the patient

Exclusion Criteria

Pre-existing uncontrolled cardiac disease, signs of cardiac failure, or rhythm disturbances requiring therapy
Cardiac Pacemaker
Myocardial infarction within the past 12 months
Congestive heart failure
Complete bundle branch block
New York Heart Association (NYHA) class III or IV heart disease
Disease that would preclude chemoradiation or deep regional hyperthermia
Metal implants (length > 2cm or dense clusters of marker clips in the pelvis)
Active or therapy-resistent bladder infections
Pre-existing or concommitant immunodeficiency Syndrome
Pregnant or lactating women
Patients not willing to use effective contraception during and up to 6 months after therapy
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact



Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider


Browse trials for

Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 



Reply by • Private

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note