Vitamin D Supplementation and Tibia Fracture. Does it Improve Healing Rate?

  • End date
    Aug 18, 2023
  • participants needed
  • sponsor
    Hospital del Trabajador de Santiago
Updated on 21 January 2021
vitamin d supplementation
fracture treatment
25 hydroxyvitamin d


This study evaluates the effect of Vitamin D3 supplementation in healing rate of tibia fractures in adult patients with low vitamin D. Half of participants will receive Vitamin D3 supplementation while the other will receive placebo.

Condition Vitamin D Deficiency, Fracture, Fracture Healing, Fracture of tibia, Vitamin Deficiency, Bone Fractures
Treatment Placebo, Vitamin D3.
Clinical Study IdentifierNCT03232216
SponsorHospital del Trabajador de Santiago
Last Modified on21 January 2021


Yes No Not Sure

Inclusion Criteria

Tibial fracture
ASA physical status classification system I-II
hydroxyvitamin D below 30ng/ml)
Fracture treatment with reamed intramedullary nail

Exclusion Criteria

Open Fractures Gustillo III B and III C
Closed Soft tissue injury with Tscherne classification of III
Acute Compartment Syndrome
Pathology fractures (That occur in abnormal bone, for example in the presence of tumor, cyst or Paget disease)
Other Fractures in lower limbs or spine that does not allow full weight bearing of the operated tibia after 4 weeks
More than 7 days of evolution from fracture occurrence
Diabetes mellitus with HbA1c more or equal than 7%
Peripheral vascular disease
Pre-existing disorders of the metabolism of Vitamin D and/or homeostasis of calcium and phosphorous (ie. Hepatic insufficiency, congenital defects of the vitamin D metabolism, disorders of the parathyroid glands, hypo or hyper calcemia)
Renal failure with glomerular filtration rate below 60ml/min according to MDRD-4
Patients using nephrotoxic medications in high doses, requiring periodical monitoring of glomerular filtration rate
Patients undergoing with nephrotic syndrome or that suffered it in the past
Patients that suffered nephrolithiasis or urolithiasis
Pregnant women
Patients with allergy to vitamin D or other contraindications for vitamin D3 prescription
Patients that are taking multivitamin supplements containing vitamin D and will not suspend taking them during the study
Patients that are not able to swallow a cup of water
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact



Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider


Browse trials for

Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 



Reply by • Private

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note